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首页> 外文期刊>Endocrinology >The rhythmic secretion of mating-induced prolactin secretion is controlled by prolactin acting centrally.
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The rhythmic secretion of mating-induced prolactin secretion is controlled by prolactin acting centrally.

机译：交配诱导的催乳激素分泌的节律性分泌受催乳素集中控制。

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Artificial copulomimetic cervical stimulation (CS) induces an immediate release of oxytocin (OT) and prolactin (PRL) followed by a daily PRL rhythm characterized by nocturnal and diurnal surges. Although we have shown that the initial release of PRL is induced by the immediate release of OT, we tested whether the PRL that is released in response to CS is responsible for the initiation and maintenance of the subsequent PRL surges. Thus, we injected OVX rats centrally or peripherally with ovine PRL (oPRL) at 2200 h. Central oPRL induced PRL surges in OVX rats that were similar in size and timing to those of CS rats, whereas peripheral oPRL induced surges that were of smaller amplitude and delayed. We then infused a PRL antagonist (S179D, 0.1 ng/h) centrally into OVX and OVX-CS rats and measured the release of endogenous PRL and the activity of neuroendocrine dopaminergic neurons. Central infusion of S179D did not influence basal PRL secretion in OVX rats but prevented the expression of the CS-induced PRL surges and the accompanying noontime increase of CS-induced dopaminergic activity when continued for 3 d. However, central infusion of S179D only on the day of CS did not prevent the daily rhythm of PRL surges. These results demonstrate that PRL acts centrally to induce the PRL rhythm and that PRL in the brain is essential for the maintenance but not for the initiation of the CS-induced rhythmic PRL surges.
机译：人工拟交催乳剂宫颈刺激（CS）诱导催产素（OT）和催乳素（PRL）立即释放，然后以夜间和昼夜潮为特征的每日PRL节律。尽管我们已经表明PRL的初始释放是由OT的立即释放引起的，但是我们测试了响应CS释放的PRL是否负责随后PRL激增的维持和启动。因此，我们在2200小时时向OVX大鼠中心或周围注射绵羊PRL（oPRL）。中央oPRL诱导OVX大鼠PRL激增，其大小和时间与CS大鼠相似，而外围oPRL诱导的幅度更小且延迟。然后，我们将PRL拮抗剂（S179D，0.1 ng / h）集中注入OVX和OVX-CS大鼠，并测量内源性PRL的释放和神经内分泌多巴胺能神经元的活性。持续输注3天后，S179D的中央输注不会影响OVX大鼠的基础PRL分泌，但会阻止CS诱导的PRL激增的表达以及随之而来的中午CS诱导的多巴胺能活性的增加。但是，仅在CS当天集中输注S179D并不能阻止PRL激增的每日节律。这些结果表明，PRL的作用主要是诱导PRL的节律，而大脑中的PRL对于维持保养至关重要，但对于CS引起的有节奏的PRL激增却不是必需的。

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