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首页> 外文期刊>Endocrinology >Myofiber Androgen Receptor Promotes Maximal Mechanical Overload-Induced Muscle Hypertrophy and Fiber Type Transition in Male Mice
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Myofiber Androgen Receptor Promotes Maximal Mechanical Overload-Induced Muscle Hypertrophy and Fiber Type Transition in Male Mice

机译：肌纤维雄激素受体促进雄性小鼠最大的机械超负荷诱导的肌肉肥大和纤维类型转变。

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The first aim of this study was to examine the role of myofiber androgen receptor (AR) in male mice on muscle performance gain and remodeling-induced muscle mechanical overloading (OVL) that mimics resistance training. The response of OVL in mice in which AR is selectively ablated in myofibers (AR(skm-/y)) was compared with that of wild-type (WT) mice. In addition, we determined whether the synthetic anabolic androgen nandrolone administration affects the OVL response. We found that OVL increased absolute maximal force and fatigue resistance in both mouse genotypes (P < .05). However, the absolute maximal force increased more in AR(skm-/y) mice as compared with WT mice (+88% vs +63%) (P < .05). Muscle weight increased less in response to OVL in AR(skm-/y) mice (+54%) than in WT mice (+115%) (P < .05). The fiber number per cross-section similarly increased in both mouse genotypes after OVL (P < .05). In contrast to WT mice, the diameter of the fibers expressing myosin heavy chain (MHC)-2x decreased after OVL in AR(skm-/y) mice (P < .05). The MHC-2b to MHC-2a fiber type transition in response to OVL was reduced in AR(skm-/y) mice as compared with WT mice (P < .05). Finally, nandrolone administration during OVL did not further improve absolute maximal force and fatigue resistance and markedly alter muscle remodeling in both mouse genotypes. Together, our results indicate that myofiber AR is required for a complete response to OVL and that exogenous androgens do not increase muscle performance during intensive remodeling in male mice.
机译：这项研究的第一个目的是检查雄性小鼠中的肌纤维雄激素受体（AR）在模仿模仿阻力训练的肌肉性能提高和重塑诱导的肌肉机械超负荷（OVL）方面的作用。比较了在野生型（WT）小鼠中AR在肌纤维（AR（skm- / y））中被选择性消融的小鼠中OVL的反应。此外，我们确定合成的合成代谢雄性激素nandrolone是否会影响OVL反应。我们发现OVL在两种小鼠基因型中均增加了绝对最大力和抗疲劳性（P <.05）。但是，与WT小鼠相比，AR（skm- / y）小鼠的绝对最大力增加了更多（+ 88％对+63％）（P <.05）。 AR（skm- / y）小鼠（+ 54％）对OVL的反应肌肉重量增加少于WT小鼠（+ 115％）（P <.05）。在OVL之后，两种小鼠基因型中每个横截面的纤维数量均类似增加（P <.05）。与野生型小鼠相比，AR（skm- / y）小鼠中表达肌球蛋白重链（MHC）-2x的纤维直径在OVL后降低（P <.05）。与野生型小鼠相比，AR（skm- / y）小鼠响应OVL的MHC-2b到MHC-2a纤维类型转变减少（P <.05）。最后，OVL期间的nandrolone给药不能进一步改善绝对最大力和抗疲劳性，并且在两种小鼠基因型中均显着改变肌肉重塑。在一起，我们的结果表明，肌纤维AR是完整应答OVL所必需的，并且在雄性小鼠的强烈重塑过程中，外源性雄激素不会增加肌肉性能。

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