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首页> 外文期刊>Endocrinology >Control of the hypothalamo-pituitary-adrenal axis in the neonatal period: adrenocorticotropin and corticosterone stress responses dissociate in vasopressin-deficient brattleboro rats.
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Control of the hypothalamo-pituitary-adrenal axis in the neonatal period: adrenocorticotropin and corticosterone stress responses dissociate in vasopressin-deficient brattleboro rats.

机译：新生儿期下丘脑-垂体-肾上腺轴的控制：肾上腺皮质激素和肾上腺皮质激素的应激反应在血管加压素缺乏的布拉特伯勒大鼠中解离。

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In adulthood the hypothalamo-pituitary-adrenal axis is controlled by both CRH and arginine vasopressin (AVP). However, in neonates CRH secretion is very low, whereas AVP secretion is fully functional. This suggests that the role of AVP is more pronounced in young than in adult rats. We investigated the role of AVP by studying stress responses in 5, 10, and 20-d-old AVP-deficient Brattleboro rats. Two different stressors were applied: 24-h maternal separation and Hypnorm Grove Oxford UK injections. In heterozygous controls (that do express AVP), both stressors increased plasma ACTH and corticosterone. The ACTH stress response disappeared in AVP-deficient rats, demonstrating that during the perinatal period, the secretion of this hormone is controlled by AVP. Surprisingly, corticosterone responses remained intact in AVP-deficient rats. Similar findings were obtained after 1-, 4-, 12-, and 24-h long maternal separations. Thus, preserved corticosterone stress responses were not explained by changes in the timing of ACTH secretion. In vitro experiments suggested that the dissociation of ACTH and corticosterone stress responses can only be partly explained by higher ACTH responsiveness of the adrenal cortex in AVP-deficient rats. Together, our results show that in neonatal periods, AVP is crucial for the expression of ACTH stress responses, but neither AVP nor ACTH is necessary for the induction of corticosterone stress responses. Discrepant ACTH and corticosterone stress responses may reflect compensatory mechanisms activated by AVP deficiency, but disparate findings suggest that they rather depict a neonate-specific mechanism of hypothalamo-pituitary-adrenal-axis control.
机译：在成年期，下丘脑-垂体-肾上腺轴受CRH和精氨酸加压素（AVP）的控制。但是，在新生儿中，CRH的分泌非常低，而AVP的分泌却是完全正常的。这表明AVP的作用在成年大鼠中比在成年大鼠中更为明显。我们通过研究5、10和20日龄AVP缺陷型Brattleboro大鼠的应激反应来研究AVP的作用。应用了两种不同的压力源：24小时产妇分离和Hypnorm Grove Oxford Oxford UK注射。在杂合对照（确实表达AVP）中，两个应激源均增加血浆ACTH和皮质酮。 ACTH应激反应在AVP缺乏的大鼠中消失，表明在围产期，该激素的分泌受AVP控制。出人意料的是，在AVP缺乏的大鼠中皮质酮反应仍然完整。经过1个小时，4个小时，12个小时和24个小时的孕产妇分离，也获得了类似的发现。因此，保留的皮质类固醇应激反应不能通过ACTH分泌时间的变化来解释。体外实验表明，ACTH和皮质酮应激反应的解离只能部分解释为AVP缺陷大鼠肾上腺皮质对ACTH的较高反应性。总之，我们的结果表明，在新生儿期，AVP对于ACTH应激反应的表达至关重要，但是AVP和ACTH都不是诱导皮质酮应激反应所必需的。不一致的ACTH和皮质酮应激反应可能反映了AVP缺乏激活的代偿机制，但不同的发现表明，他们更确切地描述了下丘脑-垂体-肾上腺轴控制的新生儿特异性机制。

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