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Overview of prostate anatomy, histology, and pathology.

机译:前列腺解剖学,组织学和病理学概述。

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摘要

The human prostate is heterogeneous with regard to its embryologic origin. The two most prevalent diseases of aging males, benign prostatic hyperplasia and prostate cancer (PCa), arise from different zones within the prostate. The biology of PCa is also heterogeneous and even within a single individual there often exist prostate cancers with varying potential to progress and metastasize. Through careful study of the histology and molecular signatures of both the human and mouse-modeled disease, treatment decisions can be tailored to individual cases so as to optimize efficacy and minimize side effects from therapy.
机译:就其胚胎起源而言,人类前列腺是异质的。男性衰老的两种最普遍的疾病是良性前列腺增生和前列腺癌(PCa),它们来自前列腺内的不同区域。 PCa的生物学也是异质的,即使在单个个体中,也经常存在前列腺癌,其进展和转移的潜力各不相同。通过仔细研究人类和小鼠模型疾病的组织学和分子特征,可以针对具体情况制定治疗决策,以优化疗效并最大程度地减少治疗的副作用。

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