The pivotal role of insulin-like growth factor I in normal mammary development.

Kleinberg DL; Barcellos Hoff MH

首页> 外文期刊>Endocrinology and Metabolism Clinics of North America >The pivotal role of insulin-like growth factor I in normal mammary development.

【24h】

The pivotal role of insulin-like growth factor I in normal mammary development.

机译：胰岛素样生长因子I在正常乳腺发育中的关键作用。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Mammary development begins in puberty in response to an estrogen (E(2)) surge. E(2) does not act alone. It relies on pituitary growth hormone (GH) to induce insulin-like growth factor I (IGF-I) production in the mammary stromal compartment. In turn, IGF-I permits E(2) (and progesterone) action. During puberty, E(2) and IGF-I synergize for ductal morphogenesis. During pregnancy, progesterone joins IGF-I and E(2) to stimulate secretory differentiation necessary to produce milk. Prolactin stimulates milk production, while transforming growth factor-beta inhibits proliferation. The orchestrated action of hormones, growth factors, and receptors necessary for mammary development and function are also critical in breast cancer.

机译：乳腺发育开始于青春期，以响应雌激素（E（2））激增。 E（2）并不单独起作用。它依赖于垂体生长激素（GH）在乳腺基质区隔中诱导胰岛素样生长因子I（IGF-1）的产生。反过来，IGF-I允许E（2）（和孕激素）起作用。在青春期期间，E（2）和IGF-I协同促进导管形态发生。在怀孕期间，黄体酮会加入IGF-I和E（2）来刺激产生牛奶所必需的分泌分化。催乳素刺激乳汁生成，而转化生长因子-β则抑制增殖。乳腺发育和功能所需的激素，生长因子和受体的协调作用在乳腺癌中也很重要。

著录项

来源
《Endocrinology and Metabolism Clinics of North America》 |2011年第3期|共12页
作者
Kleinberg DL; Barcellos Hoff MH;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词

相似文献

外文文献
中文文献
专利

1. The pivotal role of insulin-like growth factor I in normal mammary development. [J] . Kleinberg DL, Barcellos Hoff MH Endocrinology and Metabolism Clinics of North America . 2011,第3期

机译：胰岛素样生长因子I在正常乳腺发育中的关键作用。
2. Current topic: the role of growth hormone and insulin-like growth factors for placental growth and development. [J] . Zumkeller W Placenta . 2000,第5a6期

机译：当前主题：生长激素和胰岛素样生长因子在胎盘生长发育中的作用。
3. Role of receptors for epidermal growth factor and insulin-like growth factors I and II in the differentiation of rat mammary glands from lactogenesis I to lactogenesis II [J] . L. E. Bussmann, I. M. Bussmann, E. H. Charreau Journal of reproduction and fertility . 1996,第2期

机译：表皮生长因子和胰岛素样生长因子I和II的受体在大鼠乳腺从生乳I到生乳II的分化中的作用
4. Insulin-like growth factors in the nervous system: characterization,biosynthesis and biological role [C] . VICKI R. SARA Society for the Study of Human Biology . 2008

机译：神经系统中胰岛素样生长因子：表征，生物合成和生物学作用
5. Potential roles for the insulin-like growth factor binding proteins during development of the mouse mammary gland. [D] . Allar, Michael Anthony. 2002

机译：胰岛素样生长因子结合蛋白在小鼠乳腺发育过程中的潜在作用。
6. Growth Hormone and Insulin-Like Growth Factor-I in the Transition from Normal Mammary Development to Preneoplastic Mammary Lesions [O] . David L. Kleinberg, Teresa L. Wood, Priscilla A. Furth, -1

机译：从正常乳腺发育到肿瘤前乳腺病变的生长激素和类胰岛素生长因子-I
7. The Mitogenic Action of Insulin-like Growth Factor I in Normal Human Mammary Epithelial Cells Requires the Epidermal Growth Factor Receptor Tyrosine Kinase [O] . Tawhid Ahmad, Gillian Farnie, Nigel J. Bundred, 2004

机译：胰岛素样生长因子I在正常人乳腺上皮细胞中的促丝胶作用需要表皮生长因子受体酪氨酸激酶

The pivotal role of insulin-like growth factor I in normal mammary development.

摘要

著录项

相似文献

相关主题

期刊订阅