Pathophysiology of Osteoporosis. New Mechanistic Insights.

ArmasL.A.G.; ReckerR.R.

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Pathophysiology of Osteoporosis. New Mechanistic Insights.

机译：骨质疏松症的病理生理学。新机制见解。

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Understanding of the pathophysiology of osteoporosis has evolved to include compromised bone strength and skeletal fragility caused by several factors: (1) defects in microarchitecture of trabeculae, (2) defective intrinsic material properties of bone tissue, (3) defective repair of microdamage from normal daily activities, and (4) excessive bone remodeling rates. These factors occur in the context of age-related bone loss. Clinical studies of estrogen deprivation, antiresorptives, mechanical loading, and disuse have helped further knowledge of the factors affecting bone quality and the mechanisms that underlie them. This progress has led to several new drug targets in the treatment of osteoporosis.

机译：对骨质疏松症的病理生理学的了解已演变为包括以下几个因素引起的骨强度和骨骼脆性受损：（1）小梁的微体系结构缺陷;（2）骨组织的固有内在材料特性缺陷;（3）正常修复微损伤的缺陷日常活动，以及（4）骨重塑率过高。这些因素发生在与年龄有关的骨质流失的背景下。雌激素剥夺，抗吸收剂，机械负荷和废弃的临床研究有助于进一步了解影响骨骼质量的因素及其背后的机制。这一进展导致了在骨质疏松症治疗中的几种新药物靶标。

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《Endocrinology and Metabolism Clinics of North America》 |2012年第3期|共12页
作者
ArmasL.A.G.; ReckerR.R.;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
Bone quality; Mechanical loading; Microdamage; Osteoporosis; Remodeling;

机译：骨骼质量;机械负荷;微损伤;骨质疏松症;重塑;

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1. Pathophysiology of Osteoporosis. New Mechanistic Insights. [J] . ArmasL.A.G., ReckerR.R. Endocrinology and Metabolism Clinics of North America . 2012,第3期

机译：骨质疏松症的病理生理学。新机制见解。
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Pathophysiology of Osteoporosis. New Mechanistic Insights.

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