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Age-Associated Abnormalities of Water Homeostasis

机译：与年龄相关的水动态平衡异常

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Findley first proposed the presence of age-related dysfunction of the hypothalamic-neurohypophyseal-renal axis more than 60 years ago. More sophisticated studies have since corroborated his findings. As a result, it is now clear that multiple abnormalities in water homeostasis occur commonly with aging, and that the elderly are uniquely susceptible to disorders of body volume and osmolality. This article summarizes the distinct points along the hypothalamic-neurohypophyseal-renal axis where these changes have been characterized, as well as the clinical significance of these changes, with special attention to effects on cognition, gait instability, osteoporosis, fractures, and morbidity and mortality.
机译：芬德利（Findley）于60年前首次提出下丘脑-神经下垂体-肾轴的年龄相关性功能障碍的存在。此后，更复杂的研究证实了他的发现。结果，现在清楚的是，随着年龄的增长，水体内稳态通常会发生多种异常，并且老年人特别容易受到体量和重量克分子渗透压浓度的影响。本文总结了特征在于这些变化的下丘脑-神经下垂体-肾轴上的不同点，以及这些变化的临床意义，并特别关注对认知，步态不稳，骨质疏松，骨折以及发病率和死亡率的影响。

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