This issue on diabetic complications provides discussion of both basic pathophysi-ology and practical treatment for both researchers and clinicians. The next issue will focus on conditions closely associated with diabetes. Given the epidemic of obesity and type 2 diabetes, these are most timely topics for Endocrinology and Metabolism Clinics of North America. Hypoglycemia is one of the major acute complications that diabetic individuals have to deal with, especially those on sulphonylureas and insulin therapy. The risk is further increased when renal function is compromised. The normal counterregulatory response to hypoglycemia may be impaired, leading to an even more dangerous situation with increased morbidity and mortality. As Drs Alsahli and Gerich discuss, episodes of hypoglycemia can be reduced in severity and occurrence with intensive education of patients.
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