Advanced Glycation Endproducts in Diabetes and Diabetic Complications

VlassaraH.; StrikerG.E.

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Advanced Glycation Endproducts in Diabetes and Diabetic Complications

机译：糖尿病和糖尿病并发症中的高级糖基化终产物

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This review presents insights from studies of advanced glycation end products (AGEs) in humans and mice. Although the emphasis is on the effects of exogenous AGEs and the suppression of specific host defense mechanisms, AGEs are also formed intracellularly, where they may contribute to several normal intracellular functions. It is only when the overall levels of AGEs in the extracellular and the intracellular spaces exceeds the ability of the native antioxidant (and AGE) defenses that they pose a problem.

机译：这篇评论提供了来自人类和小鼠晚期糖基化终产物（AGEs）研究的见解。尽管重点放在外源性AGEs的作用和特定宿主防御机制的抑制上，但AGEs也在细胞内形成，它们可能有助于几种正常的细胞内功能。只有当细胞外和细胞内空间中AGEs的总体水平超过天然抗氧化剂（和AGE）防御能力时，它们才构成问题。

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《Endocrinology and Metabolism Clinics of North America》 |2013年第4期|共23页
作者
VlassaraH.; StrikerG.E.;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
Advanced glycation endproduct; Diabetes; Insulin resistance; Metabolism;

机译：晚期糖基化终产物;糖尿病;胰岛素抵抗;代谢;

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1. Advanced Glycation Endproducts in Diabetes and Diabetic Complications [J] . VlassaraH., StrikerG.E. Endocrinology and Metabolism Clinics of North America . 2013,第4期

机译：糖尿病和糖尿病并发症中的高级糖基化终产物
2. Increased serum high-mobility group box-1 and cleaved receptor for advanced glycation endproducts levels and decreased endogenous secretory receptor for advanced glycation endproducts levels in diabetic and non-diabetic patients with heart failure. [J] . Wang LJ, Lu L, Zhang FR, European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology . 2011,第4期

机译：糖尿病和非糖尿病心力衰竭患者血清高迁移率族box-1的增加和晚期糖基化终产物水平的裂解受体降低，内源性分泌受体的糖基化终末产物水平降低。
3. Increased serum high-mobility group box-1 and cleaved receptor for advanced glycation endproducts levels and decreased endogenousn secretory receptor for advanced glycation endproducts levels in diabetic and non-diabetic patients with heart failure [J] . Wei Feng Shen European Journal of Heart Failure . 2011,第4期

机译：糖尿病和非糖尿病心力衰竭患者血清高迁移率族box-1的增加和晚期糖基化终产物水平的裂解受体减少，内源性分泌受体的糖基化终末产物水平降低
4. THE MAILLARD REACTION - A JOURNEY FROM THE DISCOVERY OF ADVANCED GLYCATION ENDPRODUCTS TO THEIR CHIEF CELLULAR RECEPTOR, RAGE: A MECHANISM UNDERLYING DIABETIC COMPLICATIONS AND THE INFLAMMATORY RESPONSE [C] . R. Ramasamy, S.F. Yan, A.M. Schmidt International Symposium on the Maillard Reaction . 2010

机译：毛利德反应 - 从先进的糖化封端到其主要细胞受体的旅程，愤怒：糖尿病并发症的机制和炎症反应
5. Measurements of low molecular weight fluorescent advanced glycation endproducts in serum: Limitations of flow injection analysis assays for the assessment of diabetic complications [D] . O'Keeffe, Elizabeth Kathryn 2006

机译：血清中低分子量荧光高级糖基化终产物的测定：流动注射分析法在糖尿病并发症评估中的局限性
6. The Diverse Ligand Repertoire of the Receptor for Advanced Glycation Endproducts Pathways to the Complications of Diabetes [O] . Ravichandran Ramasamy, Shi Fang Yan, Ann Marie Schmidt -1

机译：该受体晚期糖化终产物途径的不同配体剧目糖尿病并发症
7. Vitreous advanced glycation endproducts and alpha-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls [O] . Fokkens, Bernardina T., Mulder, Douwe J., Schalkwijk, Casper G., 2017

机译：玻璃体晚期糖基化终产物和α-二羰基在患有2型糖尿病和非糖尿病对照的视网膜脱离患者中的作用

Advanced Glycation Endproducts in Diabetes and Diabetic Complications

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