Perinatal Programming of Metabolic Diseases. Role of Insulin in the Development of Hypothalamic Neurocircuits

SteculorumS.M.; VogtM.C.; BrüningJ.C.

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Perinatal Programming of Metabolic Diseases. Role of Insulin in the Development of Hypothalamic Neurocircuits

机译：围产期代谢性疾病的编程。胰岛素在下丘脑神经回路发育中的作用

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It is increasingly accepted that the metabolic future of an individual can be programmed as early as at developmental stages. For instance, offspring of diabetic mothers have a greater risk of becoming obese and diabetic later in life. Animal studies have demonstrated that hyperinsulinemia and/or hyperglycemia during perinatal life permanently impair the organization and long-term function of hypothalamic networks that control appetite and glucose homeostasis. This review summarizes the main findings regarding the key regulatory roles of perinatal insulin and glucose levels on hypothalamic development and on long-term programming of metabolic diseases reported in different rodent models. ? 2013 Elsevier Inc..

机译：人们越来越早地认识到，可以在发育阶段就对个体的未来进行编程。例如，糖尿病母亲的后代在以后的生活中变得肥胖和糖尿病的风险更大。动物研究表明，围产期生活中的高胰岛素血症和/或高血糖症永久性损害控制食欲和葡萄糖稳态的下丘脑网络的组织和长期功能。这篇综述总结了有关围生期胰岛素和葡萄糖水平对下丘脑发育和不同啮齿动物模型中报道的代谢性疾病的长期编程的关键调控作用的主要发现。？ 2013爱思唯尔公司

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《Endocrinology and Metabolism Clinics of North America》 |2013年第1期|共16页
作者
SteculorumS.M.; VogtM.C.; BrüningJ.C.;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
Development; Glucose; Hypothalamus; Insulin; Maternal diabetes; Maternal obesity; Perinatal programming;

机译：发育;葡萄糖;下丘脑;胰岛素;母体糖尿病;母体肥胖;围产期编程;

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1. Perinatal Programming of Metabolic Diseases. Role of Insulin in the Development of Hypothalamic Neurocircuits [J] . SteculorumS.M., VogtM.C., BrüningJ.C. Endocrinology and Metabolism Clinics of North America . 2013,第1期

机译：围产期代谢性疾病的编程。胰岛素在下丘脑神经回路发育中的作用
2. A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat [J] . M. López, L. M. Seoane, S. Tovar, Diabetologia . 2005,第1期

机译：围产期喂养对大鼠下丘脑程序中神经肽Y，刺鼠相关蛋白和瘦素受体亚型的可能作用
3. Early life origins of metabolic disease: Developmental programming of hypothalamic pathways controlling energy homeostasis [J] . Dearden Laura, Ozanne Susan E. Frontiers in neuroendocrinology . 2015,第Null期

机译：代谢性疾病的早期生命起源：控制能量稳态的下丘脑途径的发展规划
4. Commentary on the Role of Prenatal Stress in Developmental Programming of Obesity and Metabolic Dysfunction [C] . Berthold Viktor Koletzko Nestle? Nutrition Workshop . 2013

机译：对产前压力在肥胖和代谢功能障碍发展规划的作用的评论
5. Development and characterization of a novel animal model of diet-induced insulin resistant diabetes and metabolic dyslipidemia: Mechanistic interactions between dietary fructose, fat and cholesterol, and the possible role of liver X receptor in the induction of metabolic syndrome. [D] . Basciano, Heather. 2006

机译：饮食诱导的胰岛素抵抗性糖尿病和代谢性血脂异常的新型动物模型的开发和表征：饮食中的果糖，脂肪和胆固醇之间的机制相互作用，以及肝脏X受体在代谢综合征的诱导中的可能作用。
6. Analysis of Both Lipid Metabolism and Endocannabinoid Signaling Reveals a New Role for Hypothalamic Astrocytes in Maternal Caloric Restriction-Induced Perinatal Programming [O] . Rubén Tovar, Antonio Vargas, Jesús Aranda, 2021

机译：脂质代谢和内炎素标志信号的分析揭示了幼稚星形胶质细胞在母体热限制诱导的围产期编程中的新作用
7. Metabolic Programming of Hypothalamic Neurocircuits by Maternal High-Fat Feeding [O] . Vogt Merly Carlotta 2014

机译：母体高脂喂养下丘脑神经回路的代谢程序设计

Perinatal Programming of Metabolic Diseases. Role of Insulin in the Development of Hypothalamic Neurocircuits

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