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首页> 外文期刊>Endocrinology and Metabolism Clinics of North America >An integrated view of insulin resistance and endothelial dysfunction.
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An integrated view of insulin resistance and endothelial dysfunction.

机译：胰岛素抵抗和内皮功能障碍的综合观点。

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摘要

Endothelial dysfunction and insulin resistance are frequently comorbid states. Vasodilator actions of insulin are mediated by phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathways that stimulate production of nitric oxide from vascular endothelium. This helps to couple metabolic and hemodynamic homeostasis under healthy conditions. In pathologic states, shared causal factors, including glucotoxicity, lipotoxicity, and inflammation selectively impair PI3K-dependent insulin signaling pathways that contribute to reciprocal relationships between insulin resistance and endothelial dysfunction. This article discusses the implications of pathway-selective insulin resistance in vascular endothelium, interactions between endothelial dysfunction and insulin resistance, and therapeutic interventions that may simultaneously improve both metabolic and cardiovascular physiology in insulin-resistant conditions.
机译：内皮功能障碍和胰岛素抵抗常常是合并症。胰岛素的血管舒张作用由磷脂酰肌醇3-激酶（PI3K）依赖性的信号传导途径介导，该信号传导通路刺激血管内皮产生一氧化氮。这有助于在健康条件下耦合代谢和血液动力学稳态。在病理状态下，共有的因果因素（包括糖毒性，脂毒性和炎症）有选择地损害了依赖PI3K的胰岛素信号传导途径，这些途径促进了胰岛素抵抗与内皮功能障碍之间的相互关系。本文讨论了血管内皮中选择性途径胰岛素抵抗的意义，内皮功能障碍和胰岛素抵抗之间的相互作用以及在胰岛素抵抗情况下可同时改善代谢和心血管生理的治疗性干预措施。

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