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首页> 外文期刊>Bulletin of experimental biology and medicine >Clinical significance of hyperexpression of epidermal growth factor receptors (EGFR and HER-2) in esophageal squamous cell carcinoma.
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Clinical significance of hyperexpression of epidermal growth factor receptors (EGFR and HER-2) in esophageal squamous cell carcinoma.

机译：食管鳞状细胞癌中表皮生长因子受体（EGFR和HER-2）过表达的临床意义。

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Immunohistochemical study of marker expression in primary tumors of patients with esophageal squamous-cell carcinoma was carried out in order to evaluate prognostic significance of EGFR and HER-2 levels in the tumors. Hyperexpression of EGFR and HER-2 in the tumors is an important marker for the analysis of prognosis and clinical course of the disease. A relationship between high levels of EGFR and HER-2 in the tumors of patients with esophageal squamous-cell carcinoma and intravascular tumor invasion (p=0.038) and poor outcome of the disease (p=0.019) was detected. The results indicate that evaluation of changes in the expression of EGFR and HER-2 in tumors is essential for individual prediction of the disease course and development of new approaches to the treatment of these tumors, including target therapy aimed at these tyrosine kinase receptors.
机译：为了评估EGFR和HER-2水平在肿瘤中的预后意义，进行了食管鳞状细胞癌患者原发性肿瘤标志物表达的免疫组织化学研究。 EGFR和HER-2在肿瘤中的过表达是分析该病预后和临床病程的重要标志。食管鳞状细胞癌患者的肿瘤中高水平的EGFR和HER-2与血管内肿瘤浸润（p = 0.038）和疾病预后不良（p = 0.019）之间存在相关性。结果表明，评估肿瘤中EGFR和HER-2表达的变化对于个体预测病程和开发治疗这些肿瘤的新方法（包括针对这些酪氨酸激酶受体的靶向治疗）至关重要。

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