...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Electroanalysis >Electrochemical study of flutamide, an anticancer drug, and its polarographic, UV spectrophotometric and HPLC determination in tablets
【24h】

Electrochemical study of flutamide, an anticancer drug, and its polarographic, UV spectrophotometric and HPLC determination in tablets

机译：氟他胺（一种抗癌药）的电化学研究及其极谱法，紫外分光光度法和HPLC测定

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Flutamide, 4-nitro-3-trifluoromethyl-isobutylanilide a synthetic antiandrogenic with therapeutic use in prostatic cancer, is electrochemically studied to propose a new electroanalytical alternative for its quantitative determination in pharmaceutical forms. Flutamide is shown to be electrochemically reducible in aqueous and mixed media, due to the presence of the nitroaromatic moiety in the molecule. From the mixed media studies, a nitro radical anion derivative from flutamide is described. From the pH dependence of the polarographic peak an apparent pK(a) of 4.8 was obtained and corroborated by means of UV spectroscopy. Based on the linear relation between the peak current and the flutamide concentrations a differential pulse polarographic method was developed. For comparative purposes spectrophotometric and HPLCUV methodologies were developed. Furthermore the developed methods were checked for selectivity using hydrolysis, photolysis, thermolysis and chemical oxidation. [References: 19]
机译：电化学研究了氟他胺，4-硝基-3-三氟甲基-异丁基苯胺（一种合成的抗雄激素药物，在前列腺癌中的治疗用途），提出了一种新的电分析替代品，用于定量测定药物形式。由于分子中存在硝基芳族部分，因此氟他胺在水性介质和混合介质中可电化学还原。从混合介质研究中，描述了来自氟他胺的硝基自由基阴离子衍生物。从极谱峰的pH依赖性，获得了4.8的表观pK（a），并通过紫外光谱法得到证实。基于峰值电流与氟他胺浓度之间的线性关系，开发了差分脉冲极谱法。为了比较，开发了分光光度法和HPLCUV方法。此外，使用水解，光解，热解和化学氧化对开发的方法的选择性进行了检查。 [参考：19]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号