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首页> 外文期刊>Electroanalysis >Sensitive biomimetic sensor based on molecular imprinting at functionalized indium tin oxide electrodes
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Sensitive biomimetic sensor based on molecular imprinting at functionalized indium tin oxide electrodes

机译：基于分子印迹在功能化氧化铟锡电极上的敏感仿生传感器

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摘要

We initially report an electrochemical sensing platform based on molecularly imprinted polymers (MIPs) at functionalized Indium Tin Oxide Electrodes (ITO). In this research, aminopropyl-derivatized organosilane aminopropyltriethoxysilane (APTES), which plays the role of functional monomers for template recognition, was firstly self-assembled on an ITO electrode and then dopamine-imprinted sol was spin-coated on the modified surface. APTES which can interact with template dopamine (DA) through hydrogen bonds brought more binding sites located closely to the surface of the ITO electrode, thus made the prepared sensor more sensitive for DA detection. Potential scanning is presented to extract DA from the modified film, thus DA can rapidly and completely leach out. The affinity and selectivity of the resulting biomimetic sensor were characterized using cyclic voltammetry (CV). It exhibited an increased affinity for DA over that of structurally related molecules, the anodic current for DA oxidation depended on the concentration of DA in the linear range from 2 x 10(-6) M to 0.8 x 10(-3) M with a correlation coefficient of 0.9927. In contrast, DA-templated film prepared under identical conditions on a bare ITO showed obviously lower response toward dopamine in solution. It should be noted that potential scanning is a very effective approach for DA extraction, and surface modification of the electrochemical transducer with functional monomers is responsible for the development of MIPs-based highly sensitive biomimetic sensor.
机译：我们最初报告了在功能化的铟锡氧化物电极（ITO）上基于分子印迹聚合物（MIP）的电化学传感平台。在这项研究中，首先在ITO电极上自组装氨基丙基衍生的有机硅烷氨基丙基三乙氧基硅烷（APTES），它起模板识别的功能单体的作用，然后将多巴胺印迹的溶胶旋涂在改性表面上。能够通过氢键与模板多巴胺（DA）相互作用的APTES带来了更多的结合位点，这些结合位点紧邻ITO电极的表面，从而使制备的传感器对DA检测更加敏感。提出了电势扫描以从改性膜中提取DA的方法，因此DA可以快速，完全地浸出。使用循环伏安法（CV）对所得仿生传感器的亲和力和选择性进行了表征。与结构相关分子相比，它对DA的亲和力增加，DA氧化的阳极电流取决于DA的浓度，线性范围为2 x 10（-6）M到0.8 x 10（-3）M，相关系数为0.9927。相反，在相同条件下在裸露的ITO上制备的DA模板膜对溶液中的多巴胺的响应明显降低。应当注意，电势扫描是用于DA提取的非常有效的方法，并且用功能单体对电化学换能器进行表面修饰是导致基于MIPs的高灵敏度仿生传感器发展的原因。

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