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首页> 外文期刊>Electroanalysis >Glucose biosensors based on electrodes modified with ferrocene derivatives intercalated into Mg/Al layered double hydroxides
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Glucose biosensors based on electrodes modified with ferrocene derivatives intercalated into Mg/Al layered double hydroxides

机译：基于二茂铁衍生物修饰的电极的葡萄糖生物传感器，该电极嵌入Mg / Al层状双氢氧化物中

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摘要

Two amperometric biosensors based on glassy carbon electrodes (GC) modified with Mg/Al layered double hydroxides (LDHs) containing ferrocene-carboxyl ate (Fc-CO2H) or ferrocene-sulfonate (Fc-SO3H), as interlayer anions, and glucose oxidase (GOx) are presented. Amperometric detection of glucose involves the electrochemical oxidation of H2O2 mediated by the ferrocene derivative. Optimization of the biosensors construction and of the operative conditions was investigated and is discussed herein. The performances of the two biosensors were evaluated by chronoamperometry, working at low anodic potentials (+0.400 V for Fc-CO2H and +0.500 V for Fc-SO3H vs. SCE). The linearity extended up to 1.5 mM and 10.0 mM in batch and in flow conditions, respectively, for both biosensors, whereas the sensitivity was higher for the one based on Fc-CO2H (4.8 +/- 0.3 versus 2.0 +/- 0.3 mu A mM(-1)cm(-2) in batch mode, and 63.9 +/- 0.4 versus 25.8 +/- 0.4 mu A mM(-1)cm(-2) in flow mode). The biosensors display rapid response time (less than 20 s), good reproducibility, as well as good operational stability. Glucose can be accurately determined in the presence of the most common interferences that coexist in blood serum if an oxidative membrane containing nanoparticles of MnO2 is applied on the biosensors' surface.
机译：两个基于玻璃碳电极（GC）的安培生物传感器，该电极用Mg / Al层状双氢氧化物（LDH）改性，其中包含二茂铁羧酸盐（Fc-CO2H）或二茂铁磺酸盐（Fc-SO3H）作为层间阴离子和葡萄糖氧化酶（ GOx）。安培法检测葡萄糖涉及由二茂铁衍生物介导的H2O2的电化学氧化。研究了生物传感器结构和操作条件的优化。通过计时电流分析法评估了这两种生物传感器的性能，它们在低阳极电势下工作（Fc-CO2H为+0.400 V，Fc-SO3H为+0.500 V，相对于SCE）。两种生物传感器的线性度分别在批次和流动条件下分别扩展至1.5 mM和10.0 mM，而基于Fc-CO2H的线性传感器的灵敏度更高（4.8 +/- 0.3 vs 2.0 +/- 0.3μA mM（-1）cm（-2）（分批模式）和63.9 +/- 0.4 vs 25.8 +/- 0.4μAmM（-1）cm（-2）（在流模式下）。该生物传感器显示出快速的响应时间（小于20 s），良好的重现性以及良好的操作稳定性。如果将含有MnO2纳米颗粒的氧化膜应用于生物传感器的表面，则可以在血清中共存的最常见干扰物的存在下准确测定葡萄糖。

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