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Electrochemical Biosensing for Cancer Cells Based on TiO2/CNT Nanocomposites Modified Electrodes

机译：TiO2 / CNT纳米复合材料修饰电极对癌细胞的电化学生物传感

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Both TiO2 nanoparticles and carbon nanotubes have been usually utilized to modify the electrodes to enhance the detection sensitivity of biomolecular recognition. In this research, novel TiO2/CNT nanocomposites have been prepared and doped on the carbon paper as the modified electrodes. Subsequently, the redox behavior of the ferricyanide probe and the surface properties of the cancer cells coated on the modified electrodes have been investigated by using electrochemical and contact angle measurements. Compared with electrochemical signals on bare carbon paper and nanocomposite modified substrates, the significantly enhanced electrochemical signals on the modified electrodes covered with cancer cells have been observed. Meanwhile, different leukemia cells (i.e., K562/ADM cells and K562/B.W. Cells) Could be also recognized because of their different electrochemical behavior and hydrophilic/hydrophobic features on the modified electrodes due to the specific components on the plasma membranes of the target cells. This new strategy may have potential application in the development of the biocompatible and multi-signal responsive biosensors for the early diagnosis of cancers.
机译：TiO2纳米颗粒和碳纳米管通常都用于修饰电极，以增强生物分子识别的检测灵敏度。在这项研究中，已经制备了新型的TiO2 / CNT纳米复合材料，并将其掺杂在碳纸上作为修饰电极。随后，通过使用电化学和接触角测量研究了铁氰化物探针的氧化还原行为和涂覆在修饰电极上的癌细胞的表面性质。与在裸碳纸和纳米复合材料修饰基材上的电化学信号相比，已观察到在被癌细胞覆盖的修饰电极上电化学信号显着增强。同时，由于靶细胞质膜上的特定成分，不同的白血病细胞（即K562 / ADM细胞和K562 / BW细胞）在修饰电极上的电化学行为和亲水/疏水特性也不同，因此也可以被识别。这种新的策略可能在开发用于癌症早期诊断的生物相容性和多信号反应性生物传感器方面具有潜在的应用价值。

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