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Capacitive biosensors [Review]

机译:电容式生物传感器[综述]

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Work on a new type of biosensor, in which changes in the dielectric properties of an electrode surface are detected, started during the late 80s. The binding of an analyte to an immobilized affinity element can be detected directly without the need for a label or an indicating reaction. The changes can be determined by measuring the electrical capacitance or impedance either by using interdigitated electrodes or more commonly by potentiostatic methods. Capacitive biosensors have been used for detection of antigens, antibodies, proteins, DNA fragments and heavy metal ions. Extremely low detection limits, down below 10(-15) M, have been reached with plugged, self-assembled recognition layers. [References: 56]
机译:新型生物传感器的工作开始于80年代后期,在该传感器中,可以检测电极表面介电特性的变化。可以直接检测分析物与固定的亲和元素的结合,而无需标记或指示性反应。可以通过使用叉指式电极或更普遍地通过恒电位法测量电容或阻抗来确定变化。电容式生物传感器已用于检测抗原,抗体,蛋白质,DNA片段和重金属离子。插入的自组装识别层已经达到了极低的检测极限,低于10(-15)M。 [参考:56]

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