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首页> 外文期刊>Electroanalysis >On-chip determination of dopamine exocytosis using mercaptopropionic acid modified microelectrodes
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On-chip determination of dopamine exocytosis using mercaptopropionic acid modified microelectrodes

机译：巯基丙酸修饰的微电极片上测定多巴胺的胞吐作用

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摘要

Gold and platinum, which often are used for thin film metallization, are not suitable for the measurement of dopamine (DA), since the oxidation product of DA forms a non-conducting polymer on the electrode surface. In this work several thiols were screened for their ability to prevent this polymerization. It was found that mercaptopropionic acid (MPA) decreased the rate of DA polymerization. MPA, possessing a weak acidic functionality, had the greatest effect on the DA electrochemistry by decreasing electrode passivation, as well as improving reversibility and sensitivity. Modifications of microchip electrodes with MPA did not only improve DA electrochemistry but also significantly increased the storage stability of the transducers. The microchips were ultimately used to detect K+ stimulated quantal release of DA from PC12 cells.
机译：经常用于薄膜金属化的金和铂不适合用于多巴胺（DA）的测量，因为DA的氧化产物在电极表面形成了非导电聚合物。在这项工作中，筛选了几种硫醇防止其聚合的能力。发现巯基丙酸（MPA）降低了DA聚合速率。具有弱酸性功能的MPA通过减少电极钝化以及提高可逆性和灵敏度，对DA电化学的影响最大。用MPA修饰微芯片电极不仅可以改善DA电化学，而且可以显着提高换能器的存储稳定性。最终将微芯片用于检测K +刺激的PC12细胞中DA的定量释放。

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