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首页> 外文期刊>Electroanalysis >Efficient electrocatalytic detection of epinephrine at gold electrodes modified with self-assembled metallo-octacarboxyphthalocyanine complexes
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Efficient electrocatalytic detection of epinephrine at gold electrodes modified with self-assembled metallo-octacarboxyphthalocyanine complexes

机译：自组装金属-八羧基酞菁配合物修饰的金电极上肾上腺素的高效电催化检测

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摘要

Electrocatalysis of epinephrine at gold electrode pre-modified with the self-assembled monolayer of cysteamine and subsequently integrated with novel metallo-octacarboxyphthalocyanine (MOCPc where M=Fe, Co and Mn) complexes (Au-Cys-MOCPc) was investigated. The electrodes showed response to the presence of epinephrine. The oxidation peak potential (E-p/V vs. Ag vertical bar AgCl, sat'd KCl) and charge transfer resistance (R-ct (k Omega)) in epinephrine solution depend markedly on the central metal of the phthalocyanine cores: Au-Cys-FeOCPc < Au-Cys-MnOCPc < Au-Cys-CoOCPc. All the electrodes showed first order electrode kinetics in [epinephrine]; the Au-Cys-FeOCPc electrode exhibited catalytic rate constant (k(ch) - 4.1 x 10(7) M-1 s(-1)) which is higher than that of the Au-cys-CoOCPc or Au-cys-MnOCPc electrode. Mechanism, recognizing the mediation of the electrocatalytic process by the central M(II)/M(III) redox processes was proposed. Epinephrine electro-oxidation at the Au-cys-FeOCPc electrode was studied in more details for the response characteristics. The diffusion coefficient of epinephrine was evaluated as (2.62 +/- 0.23) x 10(-1)cm(2) s(-1). it was established that Au-Cys-FeOCPc is suitable for sensitive determination of epinephrine in physiological pH (7.40) conditions showing linear concentration range of up to 300 nM, with excellent sensitivity (0.53 +/- 0.01 nA nM(-1)), and very low limits of detection (13.8 nM) and quantification (45.8 nM). The peak separation between ascorbic acid and epinephrine is large enough (190 mV) to permit simultaneous determination of both epinephrine and ascorbic acid in physiological pH 7.4 conditions using the Au-cys-FeOCPc electrode. Au-cys-FeOCPc electrode was successfully used for the determination of epinephrine in epinephrine hydrochloric acid injection with recovery of ca. 98.4%.
机译：研究了用半胱胺的自组装单层预修饰的金电极上肾上腺素的电催化作用，然后将其与新型金属八羧基酞菁（MOCPc，其中M = Fe，Co和Mn）配合物（Au-Cys-MOCPc）集成。电极显示出对肾上腺素的反应。肾上腺素溶液中的氧化峰电位（Ep / V vs. Ag垂直条AgCl，饱和KCl）和电荷转移电阻（R-ct（k Omega））明显取决于酞菁核的中心金属：Au-Cys -FeOCPc

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