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首页> 外文期刊>Electroanalysis >Using Capsaicin Modified Multiwalled Carbon Nanotube Based Electrodes and p-Chloranil Modified Carbon Paste Electrodes for the Determination of Amines: Application to Benzocaine and Lidocaine
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Using Capsaicin Modified Multiwalled Carbon Nanotube Based Electrodes and p-Chloranil Modified Carbon Paste Electrodes for the Determination of Amines: Application to Benzocaine and Lidocaine

机译：使用辣椒素修饰的多壁碳纳米管基电极和对氯腈修饰的碳糊电极测定胺：在苯佐卡因和利多卡因中的应用

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摘要

The utilization of the capsaicin modified carbon nanotube modified basal-plane pyrolytic graphite electrode or p-chloranil modified carbon paste electrodes are presented for the determination of pharmaceutical compounds containing amine functionality, such as benzocaine and lidocaine. In detection of benzocaine at a capsaicin modified electrode, the guaiacol functional group is irreversibly electrochemically oxidized to form the o-quinone derivative which then undergoes nucleophilic attack by the aromatic amine group in benzocaine via a 1,4-Michael addition mechanism forming a catechol-amine adduct. The electrochemically initiated formation of the capsaicin-benzocaine adduct causes a linear decrease in the voltammetric signal corresponding to capsaicin which correlates to the added concentration of benzocaine. The applicability of p-chloranil modified carbon paste electrode was also examined with the additions of benzocaine and lidocaine which resulted in a decrease in the voltammetric signals of p-chloranil, which is again due to the formation of an adduct via a similar mechanism to that described above.
机译：提出了利用辣椒素修饰的碳纳米管修饰的基面热解石墨电极或对氯苯醌修饰的碳糊电极来测定含胺官能度的药物化合物，例如苯佐卡因和利多卡因。在辣椒素修饰的电极上检测苯佐卡因时，愈创木酚官能团被不可逆地电化学氧化形成邻醌衍生物，然后邻苯二卡因中的芳香胺基通过1,4-迈克尔加成机理遭受邻苯二酚的亲核攻击，形成儿茶酚-胺加合物。辣椒素-苯佐卡因加合物的电化学引发形成导致对应于辣椒素的伏安信号线性下降，这与苯佐卡因的添加浓度相关。还通过添加苯佐卡因和利多卡因检查了对氯苯醌修饰的碳糊电极的适用性，这导致对氯苯胺的伏安信号降低，这再次是由于通过与以下相似的机理形成了加合物以上所述。

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