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首页> 外文期刊>Electroanalysis >Voltammetric and DFT studies on viloxazine: Analytical application to pharmaceuticals and biological fluids
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Voltammetric and DFT studies on viloxazine: Analytical application to pharmaceuticals and biological fluids

机译：维洛嗪的伏安法和DFT研究：在制药和生物流体中的分析应用

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The oxidative behavior of viloxazine was studied at a glassy carbon electrode in different buffer systems using cyclic, differential pulse and square-wave voltammetry. The oxidation process was shown to be diffusion-controlled and irreversible over the studied pH. The voltammetric study of the model compounds, 2-ethoxyanisole and morpholine, associated with quantum mechanical (DFT) calculations, allowed to elucidate the oxidation mechanism of viloxazine. An analytical method was developed for the quantification of viloxazine using an acetate pH 5 buffer solution as a supporting electrolyte. A linear response was obtained in the range 7 to 45 mu M, with a detection limit of 0.8 mu M. Validation parameters such as sensitivity, precision and accuracy were evaluated. The proposed method was successfully applied to the determination of viloxazine in pharmaceutical formulations and in human serum. The results were statistically compared with those obtained through an established high-performance liquid chromatography technique, no significant differences having been found between the two methods.
机译：使用循环，微分脉冲和方波伏安法研究了在不同缓冲系统中玻碳电极上的viloxazine的氧化行为。在所研究的pH值范围内，氧化过程显示出可扩散控制且不可逆。对模型化合物2-乙氧基苯甲醚和吗啉的伏安研究与量子力学（DFT）计算有关，从而阐明了维洛嗪的氧化机理。开发了一种分析方法，用于定量使用醋酸盐pH 5缓冲溶液作为支持电解质定量的维拉嗪。在7至45μM的范围内获得线性响应，检出限为0.8μM。评估了验证参数，如灵敏度，精密度和准确性。该方法成功地用于药物制剂和人血清中维洛嗪的测定。将结果与通过已建立的高效液相色谱技术获得的结果进行统计比较，两种方法之间没有发现显着差异。

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