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首页> 外文期刊>Electroanalysis >Electrocatalytic and Analytical Response of Cobalt Phthalocyanine Modified Carbon Paste Electrodes Towards Antimalarial Endoperoxide Artemisinin
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Electrocatalytic and Analytical Response of Cobalt Phthalocyanine Modified Carbon Paste Electrodes Towards Antimalarial Endoperoxide Artemisinin

机译：酞菁钴修饰的碳糊电极对抗疟疾内过氧化物青蒿素的电催化和分析响应

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摘要

A cobalt phthalocyanine modified carbon paste electrode was constructed for the analysis of artemisinin in Artemisia annua plant. Artemisinin, a sesquiterpene endoperoxide, is a novel, important antimalarial drug and is used in the therapy against Plasmodium falciparum. The developed cobalt phthalocyanine modified electrode exhibited a significant electrocatalytic activity in presence of artemisinin when using cyclic and differential pulse voltammetry. Under optimized conditions in phosphate buffer of pH 7 a well defined voltammetric peak appeared at about - 500 mV vs. Ag/AgCl. The differential pulse voltammetric peak current of artemisinin was increased linearly with the concentration range of 2.1 x 10(-5) to 5.3 x 10(-4) M (R = 0.9997). The limit of detection (LOD) was found to be 6.5 x 10(-6) M. The modified electrode was successfully tested for detecting artemisinin in complex plant materials.
机译：构建了酞菁钴修饰的碳糊电极，用于分析青蒿植物中的青蒿素。青蒿素是倍半萜内过氧化物，是一种新型的重要抗疟药，用于抗恶性疟原虫。当使用循环和差分脉冲伏安法测定时，开发的钴酞菁修饰电极在青蒿素存在下显示出显着的电催化活性。在pH 7的磷酸盐缓冲液的最佳条件下，相对于Ag / AgCl，在约-500 mV处出现了明确定义的伏安峰。青蒿素的差分脉冲伏安峰值电流随着浓度范围从2.1 x 10（-5）到5.3 x 10（-4）M线性增加（R = 0.9997）。发现的检出限（LOD）为6.5 x 10（-6）M。修饰的电极已成功测试用于检测复杂植物材料中的青蒿素。

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