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首页> 外文期刊>Electroanalysis >Single-walled carbon nanotubes modified gold electrodes as an impedimetric DNA sensor
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Single-walled carbon nanotubes modified gold electrodes as an impedimetric DNA sensor

机译：单壁碳纳米管修饰的金电极作为阻抗DNA传感器

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摘要

A gold surface modified with a self-assembled monolayer of 11-amino-1-undecanethiol (AUT) was used for the covalent immobilization of oxidized single-walled carbon nanotubes (SWNTs). The as-described SWNTs-modified substrate was subsequently used to attach single-stranded deoxyribonucleic acid (ssDNA) used as a substrate for DNA hybridization. Electrochemical impedance spectroscopy measurements were performed to follow the DNA hybridization process by using the redox couple [Fe(CN)_6]~(3-/4-)as a marker ion. Specifically, changes in charge transfer resistance obtained from the Nyquist plots were used as the sensing parameter of DNA hybridization. The substrate sensitivity towards changes in target DNA concentration, its selectivity toward different DNA sequences and its reusability are successfully demonstrated in this report.
机译：用11-氨基-1-十一烷硫醇（AUT）自组装单层修饰的金表面用于氧化单壁碳纳米管（SWNT）的共价固定。所述的SWNTs修饰的底物随后用于附着单链脱氧核糖核酸（ssDNA），该单链脱氧核糖核酸用作DNA杂交的底物。通过使用氧化还原对[Fe（CN）_6]〜（3- / 4-）作为标记离子，进行电化学阻抗谱测量以追踪DNA杂交过程。具体而言，将从奈奎斯特图获得的电荷转移电阻的变化用作DNA杂交的感测参数。此报告成功证明了底物对目标DNA浓度变化的敏感性，对不同DNA序列的选择性及其可重复使用性。

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