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首页> 外文期刊>Electroanalysis >Simple fabrication of amperometric nitric oxide microsensors based on electropolymerized membrane films
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Simple fabrication of amperometric nitric oxide microsensors based on electropolymerized membrane films

机译：基于电聚合膜薄膜的安培型一氧化氮微传感器的简单制造

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摘要

Demand for highly sensitive, selective, and practically reliable sensors which could be easily fabricated is increasing for various applications in biological and biomedical systems. Thus, here we present a novel and simple amperometric NO microsensor based on electropolymerized polymeric films. The sensor consists of a platinized Pt disk anode (25-mm diameter) which surface is modified with electropolymerized polymer films and a Ag/AgCl wire cathode coiled around the anode. Three different electropolymerized films prepared from m-phenylenediamine (m-PD), 2,3-diaminonaphthalene (2,3-DAN), and 5-amino-1-naphthol (5A1N) are compared in terms of their permselectivity for NO over major biological interferents such as anionic nitrite, ascorbic acid, uric acid; neutral acetaminophen; and cationic dopamine. Poly-5A1N film layer among the three different polymers shows the best anti-interference characteristics for all the electroactive interferents examined. Indeed, single polymer film of electropolymerized 5A1N without any additional modification as a NO selective membrane is confirmed to be sufficient to reject anionic, neutral, as well as cationic interferents while allowing relatively high permeation of NO through it. Other analytical performance of the NO microsensor fabricated with poly-5A1N is evaluated: reliable linear dynamic range (a few tens nM to mM); sensitivity of 122.0 2.5 pA/mM; detection limit of <5.8 nM (S/N 1/43); response time, t_(90%) <5 s, which are excellent when considering the small sensor size. Another sensor design which has both an anode (poly-5A1N modified platinized Pt) and a cathode (Ag/AgCl disk) embedded in a single sensor body is also presented.
机译：对于生物和生物医学系统中的各种应用，对易于制造的高灵敏度，选择性和实用性可靠的传感器的需求正在增长。因此，在这里，我们提出了一种基于电聚合聚合物膜的新颖，简单的电流型NO微传感器。该传感器包括一个镀铂金的Pt圆盘阳极（直径25毫米），其表面用电聚合的聚合物膜进行了修饰，以及一个绕着阳极盘绕的Ag / AgCl金属丝阴极。比较了由间苯二胺（m-PD），2,3-二氨基萘（2,3-DAN）和5-氨基-1-萘酚（5A1N）制备的三种不同的电聚合膜，它们对NO的选择性高于主要生物干扰物，如阴离子亚硝酸盐，抗坏血酸，尿酸;中性对乙酰氨基酚;和阳离子多巴胺。三种不同的聚合物中的Poly-5A1N薄膜层对所检查的所有电活性干扰物显示出最佳的抗干扰特性。实际上，已证实，电聚合的5A1N的单个聚合物膜无需进行任何其他修饰即可作为NO选择性膜，足以排斥阴离子，中性以及阳离子干扰物，同时允许NO相对较高地渗透。评价了用poly-5A1N制成的NO微传感器的其他分析性能：可靠的线性动态范围（几十nM至mM）;灵敏度为122.0 2.5 pA / mM;检测限<5.8 nM（S / N 1/43）;响应时间t_（90％）<5 s，这在考虑传感器尺寸较小时非常好。还提出了另一种传感器设计，该传感器具有嵌入单个传感器主体中的阳极（poly-5A1N改性的镀铂Pt）和阴极（Ag / AgCl盘）。

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