...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Electroanalysis >A PVC Membrane Sensor for Potentiometric Determination of Atorvastatin in Biological Samples and Pharmaceutical Preparations
【24h】

A PVC Membrane Sensor for Potentiometric Determination of Atorvastatin in Biological Samples and Pharmaceutical Preparations

机译：一种用于生物样品和药物制剂中电位阿托伐他汀电位测定的PVC膜传感器

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present article reports for the first time the use of Aliquat 336S-atorvastatin as an electroactive material in a poly(vinyl chloride) matrix membrane sensor plasticized with ortho-nitrophenyl-octylether (o-NPOE) or dioctylphthalate (DOP) for determination of atorvastatin in biological samples (human plasma) and in pharmaceutical preparations. The sensor shows fast, stable and reproducible response over the concentration range of 1.0×10~(-7)- 1.0×10~(-2) molL~(-1) atorvastatin with anionic slopes of 60.94±0.2 and 58.22±0.2 and pH range of 5.0-9.0 for o-NPOE and DOP plasticized based membrane sensors, respectively. The response time of the sensor is stable and fast (10 s). Results were achieved with average recoveries of 99.5% and 99.3% and mean standard deviations of ±1.1% and ±1.4% for o-NPOE and DOP plasticized based membrane sensors, respectively. The sensor exhibits high selectivity towards atorvastatin in the presence of many anions, drug excipients and diluents. Validation of the method according to the quality assurance standards shows suitability of the proposed sensors for use in the quality control assessment of the drug.
机译：本文首次报道了Aliquat 336S-阿托伐他汀作为电活性材料在用邻硝基苯基-辛基醚（o-NPOE）或邻苯二甲酸二辛酯（DOP）增塑的聚氯乙烯基质膜传感器中测定阿托伐他汀的用途在生物样品（人血浆）和药物制剂中。该传感器在1.0×10〜（-7）-1.0×10〜（-2）molL〜（-1）阿托伐他汀的浓度范围内显示出快速，稳定和可再现的响应，阴离子斜率分别为60.94±0.2和58.22±0.2，以及o-NPOE和DOP增塑膜传感器的pH范围分别为5.0-9.0。传感器的响应时间稳定且快速（10 s）。 o-NPOE和DOP增塑膜传感器的平均回收率分别为99.5％和99.3％，平均标准偏差分别为±1.1％和±1.4％。在许多阴离子，药物赋形剂和稀释剂的存在下，该传感器对阿托伐他汀具有很高的选择性。根据质量保证标准对方法的验证表明所建议的传感器适用于药物的质量控制评估。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号