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首页> 外文期刊>Electroanalysis >A dopamine electrochemical sensor based on molecularly imprinted poly(acrylamidophenylboronic acid) film
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A dopamine electrochemical sensor based on molecularly imprinted poly(acrylamidophenylboronic acid) film

机译：基于分子印迹聚（丙烯酰胺基苯基硼酸）薄膜的多巴胺电化学传感器

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摘要

Molecularly imprinted polymeric films were prepared on the surface of a gold electrode by reductive electrochemical co-polymerization of 3-acrylamidophenylboronic acid (AABA), acrylamide (as spacer monomer), and N,N′-methylenebisacrylamide (as crosslinker monomer) in the presence of dopamine in water. The analytical determination of dopamine was investigated with this molecularly imprinted poly(AABA) film-modified gold electrode using cyclic voltammetry, electrochemical quartz crystal balance, and differential pulse voltammetry. The covalent nature of dopamine-boronic acid interaction as well as the negative charge on the molecularly imprinted polymeric film at physiological pH allowed excellent selectivity against ascorbic acid and other structurally similar interferents. The sensitivity of molecularly imprinted poly(AABA)-modified electrode was further improved by depositing a thin layer of multiwalled carbon nanotubes on the gold electrode surface prior to electropolymerization. The increased surface area due to the presence of carbon nanotubes improved the dopamine sensor's detection limit to ～20nM as determined by differential pulse voltammetry. A linear dependence of peak current in the differential pulse voltammograms was obtained over the dopamine concentration range from 50nM to 2μM.
机译：在存在下，通过3-丙烯酰胺基苯基硼酸（AABA），丙烯酰胺（作为间隔单体）和N，N'-亚甲基双丙烯酰胺（作为交联剂单体）的还原电化学共聚，在金电极表面制备分子印迹聚合物膜。在水中的多巴胺。使用循环伏安法，电化学石英晶体天平和微分脉冲伏安法，对该分子印迹聚（AABA）膜修饰的金电极进行了多巴胺的分析测定。多巴胺-硼酸相互作用的共价性质以及分子印迹聚合物膜在生理pH值下的负电荷使得对抗坏血酸和其他结构相似的干扰物具有极好的选择性。通过在电聚合之前在金电极表面沉积一层薄壁的碳纳米管，可以进一步提高分子印迹聚（AABA）修饰电极的灵敏度。由于存在碳纳米管，表面积的增加将多巴胺传感器的检测极限提高到了〜20nM（通过差动脉冲伏安法测定）。在50nM至2μM的多巴胺浓度范围内，差分脉冲伏安图中的峰值电流呈线性关系。

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