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首页> 外文期刊>Electroanalysis >Interference-Free Electrochemical Detection of Nanomolar Dopamine Using Doped Polypyrrole and Silver Nanoparticles
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Interference-Free Electrochemical Detection of Nanomolar Dopamine Using Doped Polypyrrole and Silver Nanoparticles

机译:掺杂的聚吡咯和银纳米粒子对纳米摩尔多巴胺的无干扰电化学检测

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摘要

This paper presents a new approach to detect dopamine in nanomolar range using an electrochemical sensor utilizing a composite made of chitosan-stabilized silver nanoparticles and p-toluene sulfonic acid-doped ultrathin polypyrrole film. Studies included cyclic voltammogram, amperometry, differential pulse voltammetry and also investigation by electrochemical impedance spectroscopy. A detection limit of 0.58 nM was achieved in the linear range 1×10~(-9) M to 1.2×10~(-7) M. High sensitivity towards DA, good reproducibility and long-term stability have been demonstrated without interference from ascorbic acid, uric acid, epinephrine, l-dopa, glucose. The sensing system was successfully applied for quantitative determination of dopamine in commercially available human blood serum.
机译:本文提出了一种新的方法,该方法使用电化学传感器检测纳摩尔范围内的多巴胺,该传感器使用由壳聚糖稳定的银纳米颗粒和对甲苯磺酸掺杂的超薄聚吡咯膜制成的复合材料。研究包括循环伏安法,安培法,差分脉冲伏安法以及电化学阻抗谱法的研究。在1×10〜(-9)M到1.2×10〜(-7)M的线性范围内达到了0.58 nM的检出限。对DA的高灵敏度,良好的重现性和长期稳定性已证明不​​受干扰抗坏血酸,尿酸,肾上腺素,左旋多巴,葡萄糖。该传感系统已成功用于定量测定市售人血清中的多巴胺。

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