Insight into amyloid formation using Congo Red as the electrochemical probe

Veloso A.J.; Chan T.; Wing Sze Hung V.; Lam L.; Kerman K.

首页> 外文期刊>Electroanalysis >Insight into amyloid formation using Congo Red as the electrochemical probe

【24h】

Insight into amyloid formation using Congo Red as the electrochemical probe

机译：使用刚果红作为电化学探针深入了解淀粉样蛋白的形成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The amyloid-β (Aβ) aggregation pathway is an important target for the discovery of drugs that can prevent or delay the onset of Alzheimer's disease (AD). The electrochemistry of Congo Red (CR) represents a particularly promising tool for screening of Aβ-binding therapeutics in a rapid and cost-effective format. The results of the differential pulse voltammetry (DPV) measurements were confirmed using simultaneous UV-vis analysis of the same incubated Aβ samples. The early changes in the electrochemical signals were attributed to the interaction of the Aβ oligomers with CR. The electrochemical approach, in principle, allowed monitoring small molecule-Aβ interactions on the time scale of aggregation.

机译：淀粉样β（Aβ）聚集途径是发现可以预防或延迟阿尔茨海默氏病（AD）发作的药物的重要目标。刚果红（CR）的电化学代表了一种特别有希望的工具，可用于快速且经济高效地筛选Aβ结合疗法。差动脉冲伏安法（DPV）的测量结果是通过对相同培养的Aβ样品同时进行UV-vis分析来确认的。电化学信号的早期变化归因于Aβ低聚物与CR的相互作用。原则上，电化学方法允许在聚集的时间尺度上监测小分子与Aβ的相互作用。

著录项

来源
《Electroanalysis》 |2011年第12期|共4页
作者
Veloso A.J.; Chan T.; Wing Sze Hung V.; Lam L.; Kerman K.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类电化学、电解、磁化学;
关键词
Alzheimer's disease; Amyloid-β; Congo Red; Cyclic voltammetry; UV-vis spectroscopy;

机译：阿尔茨海默氏病;淀粉样β蛋白;刚果红;循环伏安法;紫外可见光谱;

相似文献

外文文献
中文文献
专利

1. Insight into amyloid formation using Congo Red as the electrochemical probe [J] . Veloso A.J., Chan T., Wing Sze Hung V., Electroanalysis . 2011,第12期

机译：使用刚果红作为电化学探针深入了解淀粉样蛋白的形成
2. Molecules of Congo red caught hopping between insulin fibrils: a chiroptical probe of the dye-amyloid binding dynamics [J] . Dec Robert, Babenko Viktoria, Dzwolak Wojciech RSC Advances . 2016,第99期

机译：刚果红色的分子捕获胰岛素原纤维之间：染料 - 淀粉样蛋白结合动力学的阴压探针
3. Thioflavine-T and Congo Red Reveal the Polymorphism of Insulin Amyloid Fibrils When Probed by Polarization-Resolved Fluorescence Microscopy [J] . Patrick Ferrand, Wei He, Julien Duboisset The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2013,第3期

机译：极化分辨荧光显微镜探测时，硫黄素-T和刚果红揭示了胰岛素淀粉样蛋白原纤维的多态性。
4. A New Molecular Model for Congo Red-β Amyloid Interaction: Implications for Diagnosis and Inhibition of Brain Plaque Formation in Alzheimer's Disease [C] . Kristine A. Zhang, Yat Li Biosensing and nanomedicine VIII . 2015

机译：刚果红-β淀粉样蛋白相互作用的新分子模型：对阿尔茨海默病的诊断和抑制脑斑形成的意义。
5. Mechanistic and Structural Insight into Amyloid Formation by Islet Amyloid Polypeptide: Implications for Monitoring the Amylome. [D] . Wong, Amy Gar-lai. 2016

机译：胰岛淀粉状蛋白多肽对淀粉状蛋白形成的机理和结构的洞察力：对监测淀粉状蛋白的意义。
6. Binding of Congo Red to Amyloid Protofibrils of the Alzheimer Aβ9–40 Peptide Probed by Molecular Dynamics Simulations [O] . Chun Wu, Justin Scott, Joan-Emma Shea 2012

机译：分子动力学模拟探测刚果红与阿尔茨海默氏症Aβ9-40肽的淀粉样原纤维的结合。
7. Study of Amyloid β-Peptide (Aβ12-28-Cys) Interactions with Congo Red and β-Sheet Breaker Peptides Using Electrochemical Impedance Spectroscopy [O] . Raheleh Partovi-Nia, Samaneh Beheshti, Ziqiang Qin, 2012

机译：使用电化学阻抗光谱研究淀粉样蛋白β-肽（Aβ12-28-CYS）与刚果红和β-薄片断路器肽的相互作用

Insight into amyloid formation using Congo Red as the electrochemical probe

摘要

著录项

相似文献

相关主题

期刊订阅