Structural changes in components of the blood-retina barrier in rat retina during photodamage in alloxan diabetes and their correction with ascovertin

LogvinovS.V.; PlotnikovM.B.; VarakutaE.Yu.; ZhdankinaA.A.

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Structural changes in components of the blood-retina barrier in rat retina during photodamage in alloxan diabetes and their correction with ascovertin

机译：四氧嘧啶糖尿病光损伤过程中大鼠视网膜血-视网膜屏障成分的结构变化及其用天冬氨酸的校正

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The outer part of the blood-retina barrier was most sensitive to light exposure (6000 1x, 6 h) during photodamage. It was manifested in hemodynamic disturbances, endothelial dysfunction, and focal death of the pigment epithelium. The photo effects increased during alloxan diabetes. The specific area of open vessels decreased, while the number of thrombotic vessels in the choroid increased. Administration of ascovertin improved hemodynamic parameters of the eye and decreased the specific area of focal damage.

机译：血液-视网膜屏障的外部对光损伤期间的光线曝光（6000 1x，6 h）最敏感。其表现为血流动力学障碍，内皮功能障碍和色素上皮的局灶性死亡。在四氧嘧啶糖尿病期间照片效果增强。开放血管的比表面积减少，脉络膜中的血栓形成血管的数目增加。使用阿斯廷丁改善了眼睛的血液动力学参数，并减少了局灶性损伤的特定区域。

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《Bulletin of experimental biology and medicine》 |2007年第6期|共4页
作者
LogvinovS.V.; PlotnikovM.B.; VarakutaE.Yu.; ZhdankinaA.A.;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Alloxan diabetes; Ascovertin; Blood-retina barrier; Light;

机译：四氧嘧啶糖尿病;天青素;血视网膜屏障;轻;

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1. Structural changes in components of the blood-retina barrier in rat retina during photodamage in alloxan diabetes and their correction with ascovertin [J] . LogvinovS.V., PlotnikovM.B., VarakutaE.Yu., Bulletin of experimental biology and medicine . 2007,第6期

机译：四氧嘧啶糖尿病光损伤过程中大鼠视网膜血-视网膜屏障成分的结构变化及其用天冬氨酸的校正
2. Altered expression of genes related to blood-retina barrier disruption in streptozotocin-induced diabetes. [J] . Klaassen I, Hughes JM, Vogels IM Experimental Eye Research . 2009,第1期

机译：链脲佐菌素诱发的糖尿病中与血-视网膜屏障破坏有关的基因表达改变。
3. Estrogen attenuates VEGF-initiated blood-retina barrier breakdown in male rats. [J] . Chen X, Zhang M, Jiang C, Hormone and Metabolic Research . 2011,第9期

机译：雌激素可减轻雄性大鼠中VEGF引发的血液-视网膜屏障的破坏。
4. Structural features of blood lymphocytes according to data of atomic force microscopy in alloxan induced diabetic rats [C] . Olga V. Stolbovskaya, Radik M. Khayrullin, Boris B. Kostishko, SPIE Conference on Optical Technologies in Biophysics and Medicine . 2018

机译：血液淋巴细胞的结构特征根据Alloxan诱导糖尿病大鼠原子力显微镜数据的数据
5. Localizing Structural and Functional Damage in the Neural Retina of Adolescents with Type 1 Diabetes. [D] . Tan, Wylie. 2012

机译：在1型糖尿病青少年的神经视网膜中定位结构和功能损伤。
6. Experimental Diabetes Causes Breakdown of the Blood-Retina Barrier by a Mechanism Involving Tyrosine Nitration and Increases in Expression of Vascular Endothelial Growth Factor and Urokinase Plasminogen Activator Receptor [O] . Azza B. El-Remessy, M. Ali Behzadian, Gamal Abou-Mohamed, 2003

机译：实验性糖尿病通过涉及酪氨酸硝化的机制引起血视网膜屏障的破坏并增加血管内皮生长因子和尿激酶纤溶酶原激活物受体的表达
7. Experimental Diabetes Causes Breakdown of the Blood-Retina Barrier by a Mechanism Involving Tyrosine Nitration and Increases in Expression of Vascular Endothelial Growth Factor and Urokinase Plasminogen Activator Receptor [O] . El-Remessy, Azza B., Behzadian, M. Ali, Abou-Mohamed, Gamal, 2003

机译：实验性糖尿病通过涉及酪氨酸硝化的机制引起血视网膜屏障的破坏，并增加血管内皮生长因子和尿激酶纤溶酶原激活物受体的表达

Structural changes in components of the blood-retina barrier in rat retina during photodamage in alloxan diabetes and their correction with ascovertin

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