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首页> 外文期刊>Endothelium: Journal of endothelial cell research >Exercise in sickle cell anemia: effect on inflammatory and vasoactive mediators.
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Exercise in sickle cell anemia: effect on inflammatory and vasoactive mediators.

机译：在镰状细胞性贫血中锻炼：对炎症和血管活性介质的影响。

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The aim of this study was to determine the response of inflammatory and vasoactive mediators to 3 consecutive days of exercise in African-American women with and without sickle cell anemia (SCA). Circulating inflammatory mediators [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha)] were measured before, and vasoactive mediators [endothelin-1 (ET-1), nitric oxide metabolites (NOx)] before and after each exercise bout in ten subjects with SCA and ten controls. Exercise did not affect ET-1, IL-6 or CRP concentrations (p >.05). TNFalpha was higher in SCA than controls (p ^ or = .0005) at all times; however, the response pattern was similar for the groups: no change from day 1 to day 2, but a decrease from day 2 to day 3 (p ?or = .05). NOx increased significantly after exercise (p < or = .0001) but returned to baseline by 24 h afterward. On the 3rd day, NOx increased after exercise in SCA but not in the controls (p Y or = .05). In conclusion, exercise did not cause a harmful inflammatory response in these individuals with SCA. However, NOx increased after exercise on all 3 days in SCA but appeared attenuated after 2 days in controls.
机译：这项研究的目的是确定患有镰刀形细胞性贫血（SCA）和不患有镰刀形细胞性贫血（SCA）的非洲裔美国妇女，运动和连续三天炎症和血管活性介质的反应。循环炎症介质[C反应蛋白（CRP），白介素6（IL-6），肿瘤坏死因子α（TNFalpha）]之前进行了测量，血管活性介质[内皮素-1（ET-1），一氧化氮代谢物（ NOx）]在十名患有SCA和十名对照的受试者每次运动之前和之后。运动并不影响ET-1，IL-6或CRP浓度（p> .05）。 SCA中的TNFalpha始终高于对照组（p ^或= .0005）;但是，各组的反应模式相似：从第1天到第2天没有变化，但是从第2天到第3天有所下降（p = 0.05）。运动后NOx显着增加（p <或= .0001），但在24小时后恢复到基线。在第3天，SCA运动后NOx升高，但对照组则没有升高（P Y或= 0.05）。总之，运动不会对这些SCA患者产生有害的炎症反应。但是，在SCA的所有3天运动后，NOx都增加了，而在对照组中的2天后，NOx却减弱了。

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