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首页> 外文期刊>Endothelium: Journal of endothelial cell research >The role of hydrogen peroxide in endothelial proliferative responses.
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The role of hydrogen peroxide in endothelial proliferative responses.

机译：过氧化氢在内皮细胞增殖反应中的作用。

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摘要

Hydrogen peroxide (H2O2) is a recently recognized second messenger regulating proliferation in mammalian cells. Endothelial cells possess NADPH oxidases, which produce the H202 precursor superoxide (.O2-) in response to receptor-mediated signaling. Multiple physiologic agents have been shown to stimulate endothelial cells to produce .O2-/H2O2, including growth factors, such as vascular endothelial growth factor and transforming growth factor-beta1, and alterations in biomechanical forces, such as shear stress and cyclic strain. Downstream effects of these stimuli can often be inhibited by scavenging H2O2. Low concentrations of H2O2 stimulate proliferation or enhanced survival in a wide variety of cell types. Also, low concentrations of H2O2 stimulate endothelial migration as well as tube formation in an in vitro model of angiogenesis. Although low concentrations of H2O2 have been shown to be involved in numerous signal transduction pathways and to independently stimulate mitogenesis, there has been little information presented on precisely how mammalian cells respond biochemically to these low concentrations of H2O2. Recently a functional proteomics approach has been utilized to identify proteins responsive to low concentrations of H2O2 in human endothelial cells.
机译：过氧化氢（H2O2）是最近公认的调节哺乳动物细胞增殖的第二信使。内皮细胞具有NADPH氧化酶，可响应受体介导的信号传导而产生H202前体超氧化物（.O2-）。已显示多种生理剂可刺激内皮细胞产生.O2- / H2O2，包括生长因子，例如血管内皮生长因子和转化生长因子-β1，以及生物力学力的变化，例如剪切应力和循环应变。这些刺激的下游效应通常可以通过清除H2O2来抑制。低浓度的H2O2可以刺激多种细胞类型的增殖或提高存活率。同样，在血管生成的体外模型中，低浓度的H2O2刺激内皮迁移以及管形成。尽管已显示低浓度的H2O2参与许多信号转导途径并独立刺激有丝分裂发生，但很少有关于哺乳动物细胞如何对这些低浓度的H2O2生化反应的信息。最近，已经使用一种功能蛋白质组学方法来鉴定对人内皮细胞中低浓度H2O2有反应的蛋白质。

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