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首页> 外文期刊>Endothelium: Journal of endothelial cell research >Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes.
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Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes.

机译：糖尿病和非糖尿病患者在急性冠状动脉综合征期间的金属蛋白酶2和-9。

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摘要

The authors hypothesized that matrix metalloproteinase (MMP)-2, -9, and tissue inhibitor metalloproteinase (TIMP)-1, -2 would be abnormal in acute coronary syndromes (ACSs). MMP-2, -9, and TIMP-1, -2 plasma levels were measured in diabetic patients with ACSs compared to nondiabetic patients with ACSs. A total of 46 diabetic and 78 nondiabetic patients with ACSs were enrolled. The following parameters were measured: body mass index (BMI), glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment index (HOMA index), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (Tg), lipoprotein(a) [Lp(a)], plasminogen activator inhibitor-1 (PAI-1), homocysteine (Hct), fibrinogen (Fg), high-sensitivity C-reactive protein (hs-CRP), and plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2. Significant HbA1c, FPG, FPI, HOMA index, DBP, Tg, Hct, and Fg increases were present in the diabetic group with ACSs, whereas hs-CRP was lower in these patients compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were higher in diabetic patients with ACSs compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were increased in diabetic patients with ACSs, which may reflect abnormal extracellular matrix metabolism in diabetes during acute event.
机译：作者假设基质金属蛋白酶（MMP）-2，-9和组织抑制剂金属蛋白酶（TIMP）-1，-2在急性冠状动脉综合征（ACS）中是异常的。与非糖尿病ACS患者相比，ACS患者糖尿病患者的MMP-2，-9和TIMP-1，-2血浆水平被测定。共有46例ACS的糖尿病患者和78例非糖尿病患者入组。测量以下参数：体重指数（BMI），糖基化血红蛋白（HbA1c），空腹血糖（FPG），空腹血浆胰岛素（FPI），体内稳态模型评估指数（HOMA指数），收缩压（SBP），舒张压血压（DBP），总胆固醇（TC），低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C），甘油三酸酯（Tg），脂蛋白（a）[Lp（a）]，纤溶酶原激活物抑制剂1（PAI-1），高半胱氨酸（Hct），纤维蛋白原（Fg），高敏C反应蛋白（hs-CRP）和血浆MMP-2，MMP-9，TIMP-1，和TIMP-2。 ACS患者在糖尿病组中HbA1c，FPG，FPI，HOMA指数，DBP，Tg，Hct和Fg显着增加，而与非ACS患者相比，这些患者的hs-CRP较低。糖尿病ACS患者的MMP-9，TIMP-1和TIMP-2血浆水平高于非糖尿病ACS患者。患有ACS的糖尿病患者的MMP-9，TIMP-1和TIMP-2血浆水平升高，这可能反映了急性期糖尿病患者细胞外基质代谢异常。

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