• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Endothelium: Journal of endothelial cell research >Vessel co-option: how tumors obtain blood supply in the absence of sprouting angiogenesis.
【24h】

Vessel co-option: how tumors obtain blood supply in the absence of sprouting angiogenesis.

机译：血管选择：在没有新生血管生成的情况下，肿瘤如何获得血液供应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The hypothesis that solid tumors are dependent on angiogenesis, the formation of new vessels, for outgrowth and metastasis has acquired a central position in cancer research and has since inspired many scientists for several decades. Among the various angiogenic stimuli that are secreted by tumor cells, members of the Vascular Endothelial Growth Factor (VEGF) family are most prominent. More recently it has become clear, however, that tumors may use alternative ways to obtain blood supply. Vessel co-option, the use of pre-existent vessels, was described first in the brain, one of the most densely vascularized organs in the body. Thus, brain tumors may develop without the need of an angiogenic switch to occur. Obviously, this way of blood supply will not be affected by angiogenesis inhibition. In addition, it is predicted that tumors with this type of behavior will be less visible in contrast-enhanced MRI. In this article we present our recently developed mouse brain model of vessel co-option in melanoma. The effects of expression of VEGF on tumor vascularity, and on MRI visualization of these brain lesions are described. Possible consequences of anti-angiogenesis therapy are discussed.
机译：实体瘤依赖于血管生成，新血管形成，生长和转移的假说在癌症研究中占据了中心位置，此后数十年来一直在激励着许多科学家。在肿瘤细胞分泌的各种血管生成刺激物中，血管内皮生长因子（VEGF）家族的成员最为突出。然而，最近已经变得很清楚，肿瘤可以使用替代方式来获得血液供应。首先在大脑中描述了血管的选择，即使用已有的血管，这是人体中血管密度最高的器官之一。因此，脑肿瘤可以发展而无需发生血管发生转换。显然，这种血液供应方式不会受到血管生成抑制的影响。另外，据预测，具有这种行为的肿瘤在造影剂增强MRI中将不那么可见。在本文中，我们介绍了我们最近开发的黑色素瘤血管选择的小鼠脑模型。描述了VEGF表达对肿瘤血管的影响以及对这些脑损伤的MRI可视化的影响。讨论了抗血管生成治疗的可能后果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号