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首页> 外文期刊>Electrochemistry communications >Study on electrochemical behavior of a diphtheria immunosensor based on silica/silver/gold nanoparticles and polyvinyl butyral as matrices
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Study on electrochemical behavior of a diphtheria immunosensor based on silica/silver/gold nanoparticles and polyvinyl butyral as matrices

机译：以二氧化硅/银/金纳米粒子和聚乙烯醇缩丁醛为基质的白喉免疫传感器的电化学行为研究

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electrochemical behavior of a diphtheria immunosensor modified with nano-size conductor and semiconductor, as a mode of silica/gold/silver nanoparticles, has been investigated. Potentiometric immunosensor, cyclic voltammetry, and electrochemical impedance techniques were used to investigate the immobilization of diphtheria antibody on silicalgold/silver colloids. In the impedance spectroscopic study, an obvious difference of the electron transfer resistance between the silica-colloid modified electrode and the gold/silver-colloid modified electrodes was observed. The cyclic voltammogram tends to be more irreversible on silica colloids. Subsequently, using the silica colloid-modified immunosensor by potentiometry as a mode, it is found that the resulting immunosensor exhibited fast potentiometric response (<3 min), high sensitivity and good reproducibility. Moreover, analytical results of several specimens obtained using the silica colloid-modified immunosensor are in satisfactory agreement with those given by the ELISA method, implying a promising alternative approach for detecting diphtheria antigen in the clinical diagnosis. (C) 2004 Elsevier B.V. All rights reserved.
机译：已经研究了纳米尺寸导体和半导体修饰的白喉免疫传感器作为二氧化硅/金/银纳米颗粒的电化学行为。使用电位免疫传感器，循环伏安法和电化学阻抗技术研究白喉抗体在硅胶/银胶体上的固定化。在阻抗谱研究中，观察到二氧化硅-胶体修饰的电极与金/银/胶体修饰的电极之间的电子转移电阻存在明显差异。循环伏安图趋于在硅胶上更不可逆。随后，通过电位计使用二氧化硅胶体修饰的免疫传感器作为模式，发现所得的免疫传感器表现出快速的电位响应（＜3分钟），高灵敏度和良好的再现性。而且，使用硅胶胶体修饰的免疫传感器获得的几个标本的分析结果与ELISA方法所给出的分析结果令人满意，这意味着在临床诊断中检测白喉抗原的一种有前途的替代方法。 （C）2004 Elsevier B.V.保留所有权利。

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