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首页> 外文期刊>Endocrine Research >The effects of hypothyroidism in rats on serum leptin concentrations and leptin mRNA levels in adipose tissue and relationship with body fat composition.
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The effects of hypothyroidism in rats on serum leptin concentrations and leptin mRNA levels in adipose tissue and relationship with body fat composition.

机译：大鼠甲状腺功能减退对脂肪组织中血清瘦素浓度和瘦素mRNA水平的影响以及与体脂成分的关系。

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Both thyroid hormones and leptin affect sympathetic nervous system activity, basal metabolic rate, body fat mass, food intake, and thermogenesis, and each one also affects the actions of the other. We examined the alterations in serum leptin concentrations and leptin mRNA expression in hypothyroid rats and investigated the relation between serum leptin and leptin mRNA levels with the total adipose tissue mass and total body weight. Twenty male Wistar rats were divided into 2 groups, euthyroid and hypothyroid. Their body compositions were examined by Dual Energy X-ray Absorptiometry at the beginning and end of the study. Serum leptin concentrations and levels of leptin mRNA in the retroperitoneal white adipose tissue were measured at the end of the study. Serum leptin concentrations did not show any difference between the two groups (1.9 +/- 0.2 ng/ml in the hypo and euthyroid group, P > 0.05), but the fat mass of the hypothyroid rats were lower than the euthyroid rats (21.1 +/- 2.5 g in the euthyroid group and 14.2 +/- 1.9 g in the hypothyroid group, P > 0.05 between groups at the end of the study) although the difference between the groups was statistically not significant. Leptin mRNA level was significantly higher in the hypothyroid group than in the euthyroid group (21.6 +/- 1.6 vs. 15.1 +/- 1.2 ng respectively, P = 0.002) although the dissected retroperitoneal fat weight was significantly lower in the hypothyroid group versus the euthyroid group (1.0 +/- 0.2 vs. 1.8 +/- 0.2 g respectively, P = 0.013). In conclusion, the change of leptin mRNA expression in white adipocytes was thought to be the direct result of hypothyroidism or a compensatory response to metabolic changes caused by hypothyroidism.
机译：甲状腺激素和瘦素都会影响交感神经系统的活动，基础代谢率，体脂量，食物摄入和生热作用，并且两者也会影响对方的作用。我们检查了甲状腺功能减退大鼠的血清瘦素浓度和瘦素mRNA表达的变化，并调查了血清瘦素和瘦素mRNA水平与总脂肪组织质量和总体重之间的关系。雄性Wistar大鼠20只分为正常甲状腺和甲状腺功能减退两组。在研究开始和结束时，通过双能X射线吸收法检查了他们的身体成分。在研究结束时测量了腹膜后白色脂肪组织中的血清瘦素浓度和瘦素mRNA水平。两组之间的血清瘦素浓度没有任何差异（次甲状腺功能正常组和甲状腺功能正常组为1.9 +/- 0.2 ng / ml，P> 0.05），但甲状腺功能减退大鼠的脂肪质量低于正常甲状腺功能的大鼠（21.1 +甲状腺功能正常组为2.5 g，甲状腺功能减退组为14.2 +/- 1.9 g，研究结束时各组之间P> 0.05），尽管两组之间的差异在统计学上不显着。甲状腺功能减退组的瘦素mRNA水平显着高于正常甲状腺组（分别为21.6 +/- 1.6和15.1 +/- 1.2 ng，P = 0.002），尽管甲状腺功能减退组的腹膜后脂肪重量明显低于正常甲状腺组。正常甲状腺组（分别为1.0 +/- 0.2和1.8 +/- 0.2 g，P = 0.013）。总之，认为白色脂肪细胞中瘦素mRNA表达的变化是甲状腺功能减退的直接结果，或者是对甲状腺功能减退引起的代谢变化的代偿反应。

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