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首页> 外文期刊>Endocrine Research >Interrelationships of GABAergic, serotoninergic and excitatory amino acid systems in its regulatory effect on prolactin secretion in prepubertal rats.
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Interrelationships of GABAergic, serotoninergic and excitatory amino acid systems in its regulatory effect on prolactin secretion in prepubertal rats.

机译：GABA能，5-羟色胺能和兴奋性氨基酸系统对青春期前催乳素分泌的调节作用之间的相互关系。

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GABAergic, serotoninergic and excitatory amino acid systems (EAAs) regulate the prolactin (PROL) secretion in prepubertal female rats. The aim of the present paper was to determine the interrelationships of these systems on the control of this pituitary hormone. It was carried out through the following scheme: 1. The participation of the EAAs and serotonin in the effect of GABAergic system on PROL release, determined by evaluating the GABA A and GABA B receptor agonists. It was carried out on animals that were previously treated with AAEs receptor antagonist or p-chlorophenylamphetamine (PCA), this one depleting serotonin in the hypothalamus. 2. The participation of GABAergic system in the effect of serotonin and EAAs systems, determined by the evaluation of the effects of EAAs receptor agonists and of 5-HTP, a serotonin precursor. With this purpose the rats were previously treated with GABA A and GABA B receptor antagonists. 3. The interrelationships between the EAAs and the serotoninergic systems in the control of PROL secretion, determined (a) by using EAAs agonists (in rats depleted of serotonin by PCA) and (b) using EAAs antagonists (in rats treated with 5-HTP, a serotonin precursor). The administration of GABAergic agonists significantly increased PROL secretion in prepubertal female rats. Neither EAAs antagonists nor the depletion of serotonin in the brain, modified the stimulatory effects of the GABAergic system on PROL levels. This is a clear indication that the activity of the GABAergic system is independent of the serotoninergic and of the EAAs system effects on the pituitary hormone. The EAAs neurotransmitter system agonists significantly increase PROL levels. This effect was blocked by the GABAergic system antagonists but was not modified by serotonin depletion. Taking into account these facts it may be considered that the GABAergic system is involved in the stimulatory effect of EAAs on PROL secretion, this effect being independent of the serotoninergic system. 5-HTP significantly increased PROL plasma levels, and this effect was modified neither by the GABAergic nor by the EAAs receptor antagonists. These results indicate that the stimulatory effect of serotonin on PROL release is independent of the GABAergic and EAAs systems. In conclusion it may be considered that in prepubertal female rats, the GABAergic and serotoninergic systems stimulate PROL secretion by independent mechanisms that do not include EAAs. On the other hand, the effects of EAAs neurotransmission are exerted via the GABAergic system.
机译：GABA能，5-羟色胺能和兴奋性氨基酸系统（EAA）调节青春期前雌性大鼠的催乳素（PROL）分泌。本文的目的是确定这些系统在垂体激素控制上的相互关系。通过以下方案进行：1.通过评估GABA A和GABA B受体激动剂，确定EAA和5-羟色胺参与GABA能系统对PROL释放的影响。它是在先前用AAEs受体拮抗剂或对氯苯基苯丙胺（PCA）治疗过的动物上进行的，这是一种在下丘脑中消耗5-羟色胺的方法。 2.通过评估EAAs受体激动剂和5-羟色胺前体5-HTP的作用来确定GABA能系统参与5-羟色胺和EAAs系统的作用。为此目的，大鼠预先用GABA A和GABA B受体拮抗剂治疗。 3.在控制PROL分泌中，EAA与5-羟色胺能系统之间的相互关系，是通过（a）使用EAAs激动剂（在PCA耗尽5-羟色胺的大鼠中）和（b）使用EAAs拮抗剂（在用5-HTP治疗的大鼠中确定的）确定的，是血清素的前体）。 GABA能激动剂的施用显着增加了青春期前雌性大鼠的PROL分泌。 EAAs拮抗剂和脑内5-羟色胺的消耗均未改变GABA能系统对PROL水平的刺激作用。这清楚地表明，GABA能系统的活性独立于5-羟色胺能，而EAAs系统对垂体激素的作用也独立。 EAAs神经递质系统激动剂可显着提高PROL水平。这种作用被GABA能系统拮抗剂所阻断，但并没有因血清素耗竭而改变。考虑到这些事实，可以认为GABA能系统参与了EAA对PROL分泌的刺激作用，该作用独立于5-羟色胺能系统。 5-HTP显着增加了PROL血浆水平，这种作用既未通过GABAergic也未通过EAAs受体拮抗剂得到改善。这些结果表明5-羟色胺对PROL释放的刺激作用独立于GABA能和EAAs系统。总之，可以认为在青春期前的雌性大鼠中，GABA能和5-羟色胺能系统通过不包含EAA的独立机制刺激PROL分泌。另一方面，EAAs神经传递的作用是通过GABA能系统发挥的。

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