Requirement of WT1 for gonad and adrenal development: insights from transgenic animals.

Vidal V; Schedl A

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Requirement of WT1 for gonad and adrenal development: insights from transgenic animals.

机译：WT1对性腺和肾上腺发育的要求：转基因动物的见解。

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Development of the gonad and adrenal gland occurs in close proximity and it has been proposed that they share a common primordium. Recent knockout and transgenic studies in mice have demonstrated that besides the orphan nuclear receptor SF1, the Wilms' tumor suppressor gene WT1 is important for gonad and adrenal gland development. WT1 is a complex gene with at least 24 isoforms produced from its locus. Although the role of each isoform is not yet understood, biochemical studies and analyses of human patients suggest that they do serve different functions in the cell. Here we present our current view of the part WT1 may play in the development of the gonad and discuss its possible role in the formation of the adrenal primordium.

机译：性腺和肾上腺的发展非常接近，有人提出它们共享一个共同的原基。最近在小鼠中进行的基因敲除和转基因研究表明，除了孤儿核受体SF1外，威尔姆斯的抑癌基因WT1对于性腺和肾上腺的发育也很重要。 WT1是一个复杂的基因，从其基因座产生至少24个亚型。尽管尚不清楚每种同工型的作用，但对人类患者的生化研究和分析表明，它们确实在细胞中发挥着不同的功能。在这里，我们介绍部分WT1在性腺发育中的作用的当前观点，并讨论其在肾上腺原基形成中的可能作用。

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《Endocrine Research》 |2000年第4期|共8页
作者
Vidal V; Schedl A;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
Adrenal Glands; DNA-Binding Proteins; Gonads; Transcription Factors; WT1-protein; 肾上腺; DNA结合蛋白质类; 性腺; 转录因子;

机译：Adrenal Glands;DNA-Binding Proteins;Gonads;Transcription Factors;WT1-protein;肾上腺;DNA结合蛋白质类;性腺;转录因子;

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1. Requirement of WT1 for gonad and adrenal development: insights from transgenic animals. [J] . Vidal V, Schedl A Endocrine Research . 2000,第4期

机译：WT1对性腺和肾上腺发育的要求：转基因动物的见解。
2. WT1 Maintains Adrenal-Gonadal Primordium Identity and Marks a Population of AGP-like Progenitors within the Adrenal Gland [J] . BandieraR., VidalV., MotamediF.J., Developmental cell . 2013,第1期

机译：WT1维持肾上腺 - 性腺原始标识，并标记肾上腺内的AGP样祖细胞的群体
3. YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. [J] . Moore AW, McInnes L, Kreidberg J, Development . 1999,第9期

机译：YAC补充表明在心外膜，肾上腺和整个肾发生过程中需要Wt1。
4. Primary rabbit epithelial cells exposed to adrenal, gonadal, and pituitary hormones in culture [C] . Stacy Hull Vance, Hamed Benghuzzi, Michelle Tucci Annual Rocky Mountain Bioengineering Symposium . 2003

机译：主要兔上皮细胞暴露于肾上腺，性腺和垂体激素的培养
5. Transgenic mice expressing AppA phytase as a model demonstrating reduced pollution in monogastric animals. [D] . Golovan, Serguei Petrovich. 2002

机译：表达AppA肌醇六磷酸酶的转基因小鼠为模型，表明单胃动物的污染减少。
6. WT1 maintains adrenal-gonadal-primordium (AGP) identity and marks a novel population of AGP-like progenitors within the adult adrenal gland [O] . Roberto Bandiera, Valerie P.I. Vidal, Fariba Ranc, -1

机译：WT1保持肾上腺-性腺原基（AGP）身份并标志着成年肾上腺中新的AGP样祖细胞群
7. WT1 Maintains Adrenal-Gonadal Primordium Identity and Marks a Population of AGP-like Progenitors within the Adrenal Gland. [O] . Bandiera, Roberto, Vidal, Valerie P I, Motamedi, Fariba Jian, 2013

机译：WT1保持肾上腺-性腺原基的身份并标记肾上腺内AGP样祖细胞的种群。
8. Eosinophil-Deficient Transgenic Animals. [R] . Lee, J. J., Lee, N. A. 2004

机译：嗜酸性粒细胞缺陷的转基因动物。

Requirement of WT1 for gonad and adrenal development: insights from transgenic animals.

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