...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Endocrine Research >No effect of simvastatin treatment on insulin sensitivity in patients with primary hypercholesterolemia.
【24h】

No effect of simvastatin treatment on insulin sensitivity in patients with primary hypercholesterolemia.

机译：辛伐他汀治疗对原发性高胆固醇血症患者的胰岛素敏感性无影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Statins, in addition to cholesterol lowering, have nonlipid effects on formation and progression of atheromatous plaque. Insulin resistance and hyperinsulinemia may have detrimental influences on the arterial wall. Statins (may also) inhibit insulin signal transferring in vascular smooth cell cultures. However, their effect on insulin sensitivity remains controversial. Therefore, we decided to investigate the effect of simvastatin on insulin sensitivity in hypercholesterolemic patients. PATIENTS AND METHODS: Eighteen patients with primary hypercholesterolemia were divided into simvastatin group (n = 9; 4 females, 5 males; BMI 30.6 +/- 4 kg/m2; mean ages 57 +/- 6 years) and placebo group (n = 9; 4 females, 5 males; BMI 28 +/- 2.9 kg/m2; mean ages 49 +/- 10 years). Simvastatin (20 mg/day) or placebo were given for 2 months. Total and HDL cholesterol were measured and LDL cholesterol was calculated by Friedewald formula. Insulin sensitivity was determined by using euglycemic hyperinsulinemic clamp technique [40 microU/m2/min insulin infusion rate; glucose disposal rate (M)= mg/kg/min] before and after treatment. RESULTS: Plasma levels of total, LDL and HDL cholesterol decreased significantly in simvastatin group after treatment (p = 0.000, p = 0.000, and p = 0.048, respectively). Plasma levels of total cholesterol decreased significantly (p = 0.032), whereas LDL and HDL levels remained unchanged in placebo group. M value (mg/kg/min) decreased insignificantly in simvastatin group (4.32 +/- 1.57 vs. 3.71 +/- 1.91) and increased in placebo group (3.55 +/- 1.91 vs. 3.95 +/- 0.95). CONCLUSION: Short-term simvastatin treatment did not affect insulin sensitivity determined by gold standard hypercholesterolemic patients in this research. Further studies with simvastatin using higher doses and longer duration should be performed.
机译：目的：他汀类药物除了可以降低胆固醇外，还对动脉粥样斑块的形成和发展具有非脂质作用。胰岛素抵抗和高胰岛素血症可能对动脉壁产生有害影响。他汀类药物（也可以）可抑制血管平滑细胞培养物中胰岛素信号的转移。但是，它们对胰岛素敏感性的作用仍存在争议。因此，我们决定研究辛伐他汀对高胆固醇血症患者胰岛素敏感性的影响。患者与方法：将18例原发性高胆固醇血症患者分为辛伐他汀组（9例;女性4例，男性5例; BMI 30.6 +/- 4 kg / m2;平均年龄57 +/- 6岁）和安慰剂组（n = 9;女性4;男性5; BMI 28 +/- 2.9 kg / m2;平均年龄49 +/- 10岁。给予辛伐他汀（20毫克/天）或安慰剂治疗2个月。测量总胆固醇和HDL胆固醇，并通过Friedewald公式计算LDL胆固醇。胰岛素敏感性通过正常血糖高胰岛素钳夹技术[40 microU / m2 / min胰岛素输注速率;治疗前后的葡萄糖处置率（M）= mg / kg / min]。结果：辛伐他汀组治疗后血浆总胆固醇，LDL和HDL胆固醇水平显着降低（分别为p = 0.000，p = 0.000和p = 0.048）。血浆总胆固醇水平显着降低（p = 0.032），而安慰剂组的LDL和HDL水平保持不变。辛伐他汀组的M值（mg / kg / min）降低不明显（4.32 +/- 1.57对3.71 +/- 1.91），而安慰剂组升高（3.55 +/- 1.91对3.95 +/- 0.95）。结论：短期辛伐他汀治疗对金标准高胆固醇血症患者的胰岛素敏感性没有影响。辛伐他汀的进一步研究应使用更大剂量和更长的持续时间。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号