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首页> 外文期刊>Endocrine Research >The relation between serum leptin levels and body fat mass in patients with active lung tuberculosis.
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The relation between serum leptin levels and body fat mass in patients with active lung tuberculosis.

机译:活动性肺结核患者血清瘦素水平与体脂量的关系。

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The relationship of leptin to diminished appetite and weight loss has been investigated in many diseases. Diminished appetite and weight loss are the most apparent characteristics of patients with active lung tuberculosis and in this study the relation of leptin to such diminished appetite and weight loss has been investigated in patients with active lung tuberculosis before and after treatment. Twenty-five patients (7 female, 18 male) with active tuberculosis having an age range of 18-70 years (mean 47.48 +/- 15.36 y) and 25 normal individuals (9 female, 16 male) having an age range of 25-71 years (mean 44.60 +/- 13.80 y) were included in this study. Leptin levels, body mass index (BMI), body fat ratio (BFR), and waist hip ratio (WHR) were measured before and after 6 months of antituberculosis treatment. The same measurements were also made in the control group and the results were compared. While the pretreatment BMI (22.02 +/- 4.31 kg/m2) and BFR (16.60% +/- 9.30%) values in the patient group were significantly lower than in the control group, we found no difference in their pretreatment WHR values. Pretreatment leptin levels (3.49 +/- 3.34 microg/L) were significantly higher in patients with tuberculosis than in the control group (2.33 +/- 1.10 microg/L). Leptin levels were found to be significantly increased at the 6th month of antituberculosis treatment (5.65 +/- 5.41 microg/L) than the pretreatment values (p < 0.05). We observed an evident increase in BMI (24.10 +/- 4.87 kg/m2) and BFR (17.51% +/- 9.25%) due to antituberculosis treatment (p < 0.05). This study suggests that leptin has a role in the diminished appetite and weight loss symptoms in patients with active lung tuberculosis.
机译:瘦素与食欲减退和体重减轻之间的关系已在许多疾病中进行了研究。食欲减退和体重减轻是活动性肺结核患者最明显的特征,在这项研究中,瘦素与食欲减退和体重减轻之间的关系已经在活动性肺结核患者治疗前后进行了研究。 25名活动性结核患者(7名女性,18名男性),年龄范围为18-70岁(平均47.48 +/- 15.36岁),以及25名正常个体(9名女性,16名男性),年龄范围为25-70岁这项研究包括71年(平均44.60 +/- 13.80年)。在抗结核治疗6个月前后,测量瘦素水平,体重指数(BMI),体脂比(BFR)和腰臀比(WHR)。对照组也进行了相同的测量,并比较了结果。尽管患者组的治疗前BMI(22.02 +/- 4.31 kg / m2)和BFR(16.60%+/- 9.30%)值显着低于对照组,但我们发现他们的治疗前WHR值没有差异。结核病患者的治疗前瘦素水平(3.49 +/- 3.34 microg / L)显着高于对照组(2.33 +/- 1.10 microg / L)。发现瘦素水平在抗结核治疗的第6个月(5.65 +/- 5.41 microg / L)明显高于治疗前的值(p <0.05)。我们观察到由于抗结核治疗,BMI(24.10 +/- 4.87 kg / m2)和BFR(17.51%+/- 9.25%)明显增加(p <0.05)。这项研究表明瘦素在活动性肺结核患者的食欲下降和体重减轻症状中起作用。

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