首页> 外文期刊>Biochimica et biophysica acta. Bioenergetics >Forty years of Mitchell's proton circuit: From little grey books to little grey cells.
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Forty years of Mitchell's proton circuit: From little grey books to little grey cells.

机译:米切尔(Mitchell)质子回路的四十年:从小灰书到小灰细胞。

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摘要

It is more than forty years since Peter Mitchell published his first 'little grey book' laying out his chemiosmotic hypothesis. Although ideas about the molecular mechanisms of the proton pumps have evolved considerably since then, his concept of 'coupling through proton circuits' remains remarkably prescient, and has provided the inspiration for the research careers of this author and many others. This review is a personal account of how the proton circuit has been followed from the little grey book, via brown fat and calcium transport to investigations into the life and death of neurons, Hercule Poirot's 'little grey cells'.
机译:彼得·米切尔(Peter Mitchell)出版了第一本“小灰皮书”,阐明了他的化学渗透假说已经40多年了。尽管自那时以来,关于质子泵分子机理的观念已经有了相当大的发展,但他的“通过质子回路耦合”的概念仍然具​​有先见之明,并为该作者和其他许多人的研究事业提供了灵感。这篇评论是关于如何从灰色的小书中追踪质子回路的个人描述,它是通过棕色脂肪和钙的运输到对神经元的生命和死亡的调查,神经元是Hercule Poirot的“小灰细胞”。

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