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Plasma levels and redox status of coenzyme Q10 in infants and children

机译：婴幼儿辅酶Q10的血浆水平和氧化还原状态

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Introduction: Increased attention has been paid to the role of lipophilic antioxidants in childhood nutrition and diseases during recent years. The lipophilic antioxidant coenzyme Q10 (CoQ10) is known as an effective inhibitor of oxidative damage. In contrast to other lipophilic antioxidants like α-tocopherol the plasma concentrations of CoQ10 in childhood are poorly researched. The aim of this study was to determine plasma level and redox status (oxidized form in total CoQ10 in %) of CoQ10 in clinically healthy infants, preschoolers and school-aged children. Methods: Plasma level and redox status of CoQ10 were measured by HPLC in 199 clinically healthy children, three groups of infants [1st-4th month (n = 35), 5th-8th month (n = 25), 9th-12th month (n = 25) ], preschoolers (n = 60) and school-aged children (n = 54). The CoQ10 plasma levels were related to plasma cholesterol concentrations. The median and the 5th and 95th percentile were calculated. Results: Plasma levels and redox status of CoQ10 in infants were significantly higher than in preschoolers and school-aged children. The CoQ10 redox status in the 1st-4th month was significantly increased when compared to the remaining subgroups of infants. In elder children the CoQ10 redox status stabilized. Conclusion: This is the first study concerning age-related values of plasma level and redox status of CoQ10 in apparently healthy children. Decreased CoQ10 values could be involved in various pathological conditions affecting childhood. Therefore, the application of age-adjusted reference values may provide more specific criteria to define threshold values for CoQ10 deficiency in plasma.
机译：简介：近年来，亲脂性抗氧化剂在儿童营养和疾病中的作用越来越受到关注。亲脂性抗氧化剂辅酶Q10（CoQ10）被称为氧化损伤的有效抑制剂。与其他亲脂性抗氧化剂（例如α-生育酚）相比，儿童期CoQ10的血浆浓度研究不足。这项研究的目的是确定在临床上健康的婴儿，学龄前儿童和学龄儿童中，CoQ10的血浆水平和氧化还原状态（总CoQ10中的氧化形式，以百分比计）。方法：通过HPLC测定了199名临床健康儿童，三组婴儿[1-4月（n = 35），5-8月（n = 25），9-12月（n]]的血浆中CoQ10的水平和氧化还原状态。 = 25），学龄前儿童（n = 60）和学龄儿童（n = 54）。 CoQ10血浆水平与血浆胆固醇浓度有关。计算了中位数以及第5个百分位数和第95个百分位数。结果：婴儿血浆中的CoQ10水平和氧化还原状态显着高于学龄前儿童和学龄儿童。与其余婴儿亚组相比，CoQ10氧化还原状态在第1至第4个月显着增加。在较大的儿童中，辅酶Q10的氧化还原状态稳定。结论：这是第一项有关年龄明显健康儿童血浆水平和CoQ10氧化还原状态的研究。降低的CoQ10值可能与影响童年的各种病理状况有关。因此，年龄调整后的参考值的应用可能会提供更具体的标准来定义血浆中CoQ10缺乏的阈值。

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