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Retinol binding protein-4 predicts incident diabetes in Asian Indian men with prediabetes

机译：视黄醇结合蛋白4预测亚洲印度裔糖尿病前期患者的糖尿病

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摘要

The association of retinol binding protein-4 (RBP4) with incident type 2 diabetes (T2DM) in Asian Indian middle-aged men with impaired glucose tolerance (IGT) was studied. This was an ancillary analysis of a subsample from a cohort of participants with IGT in a 2 year prospective diabetes prevention program in India. For this analysis, 71 incident T2DM and 76 non-diabetic cases (non-progressors) based on the final glycemic outcome were selected. Baseline serum RBP4 was measured using competitive enzyme immunoassay. Correlations of RBP4 with relevant anthropometric and biochemical variables and also its association with diabetes were assessed using appropriate statistical analyses. Participants who developed T2DM had higher levels of serum RBP4 (21.3 [IQR: 17.7-24.9] mu g/mL) compared with non-progressors (17.3 [IQR: 13.1-21.0] mu g/mL; P=0.001). Levels of RBP4 were lower than in Caucasians. Stepwise linear regression analysis showed that body mass index (BMI), systolic blood pressure, triglycerides, and HbA1c had independent associations with RBP4 levels. Multiple logistic regression analyses showed that RBP4 was independently associated with incident diabetes (odds ratio [OR] [95%confidence interval (CI)]: 1.69 [1.18-2.41]; P=0.004). Adjustment for study group, age, BMI, waist circumference, 2 H plasma glucose, triglycerides, gamma glutamyl transferase, and insulin resistance weakened the significance of its association (OR [95%CI]: 1.65 [1.03-2.66]; P=0.038).The results of this preliminary analyses showed that baseline serum RBP4 levels were independently associated with incident diabetes in Asian Indian men with IGT. It may be used as an additional predictor of future diabetes. (c) 2015 BioFactors, 41(3):160-165, 2015
机译：研究了视黄醇结合蛋白4（RBP4）与糖耐量受损（IGT）的亚洲印度裔中年男性的2型糖尿病（T2DM）的相关性。这是对印度一项为期2年的前瞻性糖尿病预防计划中IGT参与者队列的子样本的辅助分析。为了进行此分析，根据最终的血糖结果选择了71例T2DM事件和76例非糖尿病患者（非进展患者）。使用竞争性酶免疫测定法测量基线血清RBP4。使用适当的统计分析评估了RBP4与相关的人体测量学和生化变量的相关性，以及与糖尿病的相关性。与未进行治疗的参与者相比，发展为T2DM的参与者的血清RBP4水平更高（21.3 [IQR：17.7-24.9]μg / mL）（17.3 [IQR：13.1-21.0]μg / mL; P = 0.001）。 RBP4的水平低于白种人。逐步线性回归分析显示，体重指数（BMI），收缩压，甘油三酸酯和HbA1c与RBP4水平具有独立的关联。多个逻辑回归分析显示，RBP4与糖尿病的发生独立相关（几率[OR] [95％置信区间（CI）]：1.69 [1.18-2.41]; P = 0.004）。调整研究组，年龄，BMI，腰围，2 H血浆葡萄糖，甘油三酸酯，γ-谷氨酰转移酶和胰岛素抵抗削弱了其关联的意义（OR [95％CI]：1.65 [1.03-2.66]; P = 0.038 ）。这项初步分析的结果表明，亚洲印度裔IGT男性的血清RBP4基线水平与糖尿病相关。它可以用作未来糖尿病的其他预测指标。 （c）2015生物因子，2015，41（3）：160-165

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