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首页> 外文期刊>Biochimica et Biophysica Acta. Gene Regulatory Mechanisms >RNA recognition by 3'-to-5' exonucleases: The substrate perspective
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RNA recognition by 3'-to-5' exonucleases: The substrate perspective

机译：通过3'至5'核酸外切酶进行RNA识别：底物角度

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摘要

The 3'-to-5' exonucleolytic decay and processing of a variety of RNAs is an essential feature of RNA metabolism in all cells. The 3'-5' exonucleases, and in particular the exosome, are involved in a large number of pathways from 3' processing of rRNA, snRNA and snoRNA, to decay of mRNAs and mRNA surveillance. The potent enzymes performing these reactions are regulated to prevent processing of inappropriate substrates whilst mature RNA molecules exhibit several attributes that enable them to evade 3'-5' attack. How does an enzyme perform such selective activities on different substrates? The goal of this review is to provide an overview and perspective of available data on the underlying principles for the recognition of RNA substrates by 3'-to-5' exonucleases.
机译：各种RNA的3'至5'核酸外切降解和加工是所有细胞中RNA代谢的基本特征。 3'-5'核酸外切酶，特别是外泌体，参与了从rRNA，snRNA和snoRNA的3'加工到mRNA衰减和mRNA监测的多种途径。调节执行这些反应的有效酶可防止处理不合适的底物，而成熟的RNA分子则具有多种属性，可使其逃避3'-5'攻击。酶如何在不同的底物上执行这种选择性活性？这篇综述的目的是提供关于3'至5'核酸外切酶识别RNA底物的基本原理的可用数据的概述和观点。

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