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首页> 外文期刊>Equine Veterinary Education >A review of the use of moxidectin in horses.
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A review of the use of moxidectin in horses.

机译：审查莫昔克丁在马中的使用。

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Moxidectin has broad-spectrum anti-nematodal and anti-arthropodal activities in the horse but is not effective against tapeworms or flukes. Moxidectin and ivermectin have the same efficacy against internal, adult parasites of horses. Moxidectin, however, is highly effective in eliminating encysted and hypobiotic larval stages of cyathostomins, whereas ivermectin is not. Treatment of horses with moxidectin results in an egg-reappearance period (ERP) of 15-24 weeks. Because of its long ERP, moxidectin is labelled to be used at 12 week intervals. Moxidectin may provide protection against infection by ingested cyathostomin larvae for 2-3 weeks after it is administered. The larvicidal activity of moxidectin has often been compared to that of fenbendazole administered at either 7.5 or 10 mg/kg bwt for 5 consecutive days. The efficacy of fenbendazole, when administered daily for 5 consecutive days at 7.5 or 10 mg/kg bwt, against all stages of cyathostomins is often less than that of moxidectin because resistance of cyathostomins to benzimidazoles is prevalent worldwide, and the 5 day course of fenbendazole does not overcome this resistance. There are now reports of resistance of ascarids to moxidectin. Overt resistance of cyathostomins and a shortened egg re-emergence period after treatment with moxidectin have been reported. Rapid removal of manure by natural fauna can significantly reduce larval nematode concentrations and thereby reduce intervals of anthelmintic treatment. Of the macrocyclic lactones, moxidectin has the least deleterious effect on faecal fauna.
机译：Moxidectin在马中具有广谱的抗线虫和节肢动物活性，但对against虫或吸虫无效。 Moxidectin和伊维菌素对马的内部成年寄生虫具有相同的功效。然而，莫昔克丁在消除细胞分裂素的侵入和幼体幼虫阶段非常有效，而伊维菌素则不能。用莫昔克丁治疗马匹的卵重现期（ERP）为15-24周。由于其较长的ERP，moxidectin被标记为每隔12周使用一次。莫昔克丁在给药后2-3周内可提供保护，以防被吞噬的鞘脂sto幼虫感染。通常将莫西菌素的杀幼虫活性与连续5天以7.5或10 mg / kg bwt施用的芬苯达唑的杀幼虫活性进行比较。芬苯达唑在连续5天每天以7.5或10 mg / kg bwt的剂量给药时，对所有阶段的cyhosthostomins的疗效通常都低于moxidectin，因为cyathostomins对苯并咪唑的耐药性在世界范围内普遍存在，并且fenbendazole的5天疗程不能克服这种阻力。现在有报道称scar螨对莫昔克丁有抗药性。据报道，在用莫昔克丁处理后，胞嘧啶蛋白具有明显的抗药性，并且缩短了卵的重新出苗期。自然动物快速清除粪便可以显着降低幼虫线虫的浓度，从而减少驱虫治疗的间隔。在大环内酯中，莫昔克丁对粪便动物的有害作用最小。

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