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首页> 外文期刊>Equine and Comparative Exercise Physiology >Intermittent administration of human parathyroid fragment (hPTH 1 -37) on calcium and phosphorus homeostasis and bone markers in resting horses: a preliminary study
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Intermittent administration of human parathyroid fragment (hPTH 1 -37) on calcium and phosphorus homeostasis and bone markers in resting horses: a preliminary study

机译：间歇性服用人甲状旁腺片段（hPTH 1 -37）对静息马的钙和磷稳态和骨标记的影响

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摘要

Parathyroid hormone (PTH) has been shown to have anabolic and catabolic effects on the skeleton, and in young racing horses the anabolic effects of PTH on bone might be of great importance in reducing the risk of skeletal injury during race training The aim of this pilot study was to elucidate the effects of intermittent exogenous application of human parathyroid fragment (hPTH 1-37) on calcium homeostasis and bone turnover in resting horses Five horses were used in this study Horses were treated subcutaneously with hPTH (hPTH 1-37, 0.5 u-gkg~(-1) BW) daily at 600 h over a period of 28 days. A foregoing control trial was conducted under the identical test protocol without hPTH application Blood samples were taken at denned times for the control andhPTH treatment to analyze ionized Ca (Ca~(+ +) , AVL), total Ca (AAS), inorganic P_i (flame photometry), intact PTH QUA), osteocalcin (ELISA) and ICTP (carboxyterminal telopeptide of type-I collagen, RIA) Eight hours after hPTH application, blood ionizedCa~(++) (days 1 and 28) and plasma P; (days 1-28) increased significantly in comparison to the control At day 1, 8 h after hPTH application, the decrease in intact plasma PTH was more pronounced after hPTH treatment than in the control, and plasma PTH levels were higher after treatment at day 14 (16 h post-injection, P < 0 05), day 18 (16h post-injection, ns) and day 24 (Oh post-injection). There were no treatment-related differences in total plasma Ca and bone markers Intermittent PTH administration in healthy horses affected Ca and P homeostasis as well as endogenous PTH secretion, but bone turnover was not affected during the treatment period of 28 days.
机译：甲状旁腺激素（PTH）已显示对骨骼具有合成代谢和分解代谢作用，在年轻的赛马中，PTH对骨骼的合成代谢作用对于降低种族训练过程中骨骼损伤的风险可能非常重要。本研究旨在阐明间歇性外源性应用人甲状旁腺片段（hPTH 1-37）对静息马的钙稳态和骨转换的影响本研究使用了五匹马，对他们进行了皮下hPTH（hPTH 1-37，0.5 u -gkg〜（-1）BW），每天600小时，持续28天。在不使用hPTH的情况下，在相同的测试方案下进行了前述对照试验，在规定的时间采集血样进行对照和hPTH处理，以分析离子化的Ca（Ca〜（++），AVL），总Ca（AAS），无机P_i（火焰光度法），完整的PTH QUA），骨钙素（ELISA）和ICTP（I型胶原的羧基末端端肽，RIA）在应用hPTH后八小时，血液离子化Ca〜（++）（第1天和第28天）和血浆P; （1-28天）与对照组相比显着增加。在第1天，应用hPTH后8 h，hPTH治疗后完整血浆PTH的降低比对照组更为明显，治疗后第3天的血浆PTH水平更高第14天（注射后16小时，P <0 05），第18天（注射后16小时，ns）和第24天（注射后0h）。在总血浆Ca和骨标志物中没有与治疗相关的差异。在健康的马中，间歇性PTH施用会影响Ca和P稳态以及内源性PTH分泌，但是在28天的治疗期间内，骨转换不会受到影响。

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