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首页> 外文期刊>Equine and Comparative Exercise Physiology >Daily variation in plasma electrolyte and acid-base status in fasted horses over a 25 h period of rest
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Daily variation in plasma electrolyte and acid-base status in fasted horses over a 25 h period of rest

机译：在休息25小时后，禁食马匹的血浆电解质和酸碱状态的每日变化

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Measurement and interpretation of acid-base status are important in clinical practice and among racing jurisdictions to determine if horses have been administered alkalinizing substances for the purpose of enhancing performance. The present study usedthe physicochemical approach to characterize the daily variation in plasma electrolytes and acid-base state that occurs in horses in the absence of feeding and exercise. Jugular venous blood was sampled every 1-2 h from two groups (n = 4 and n = 5) of Standardbred horses over a 25 h period where food and exercise were withheld. One group of horses was studied in October and one in December. The time course and magnitude of circadian responses differed between the two groups, suggesting that subtle differences in environment may manifest in acid-base status. Significant daily variation occurred in plasma weak acid concentration ([A_(tot)]) and strong ion difference ([SID]), [Cl~-], [K~+], [Na~+] and [lactate~-], which contributed to significant changesin [H+] and TCO2. The night-time period was associated with a mild acidosis, marked by increases in plasma [H+] and decreases in TCO_2, compared with the morning hours. The night-time acidosis resulted from an increased plasma [A_(tot)] due to an increased plasma protein concentration ([PP]), and a decreased [SID] due to increases in [Cl~-] and decreases in [Na~+]. An increased plasma [K~+] during the night-time had a mild alkalotic effect. There were no differences in pCO_2. It was concluded that manyequine plasma electrolyte and acid-base parameters exhibit fluctuations in the absence of feeding and exercise, and it is likely that some of these changes are due to daily variation.
机译：酸碱状态的测量和解释在临床实践中以及在赛马管辖区中对于确定是否为了提高性能而向马匹施用碱化物质很重要。本研究使用理化方法来表征在没有进食和运动的情况下马中血浆电解质和酸碱状态的每日变化。在1-2小时内，每隔1-2小时从两组标准饲养的马中抽取颈静脉血，其中25小时不进行食物和运动。十月份对一组马进行了研究，十二月对一组进行了研究。两组之间的昼夜节律反应的时间过程和大小不同，这表明环境的细微差异可能体现在酸碱状态。血浆弱酸浓度（[A_（tot）]）和强离子差（[SID]），[Cl〜-]，[K〜+]，[Na〜+]和[乳酸盐〜-]每天发生显着变化。 ，这导致[H +]和TCO2的显着变化。与早晨相比，夜间与轻度酸中毒有关，其特征是血浆[H +]升高和TCO_2降低。夜间酸中毒是由于血浆蛋白浓度（[PP]）升高导致血浆[A_（tot）]升高，以及由于[Cl〜-]升高和[Na〜]降低而导致的[SID]降低。 +]。夜间血浆[K〜+]升高有轻度碱中毒作用。 pCO_2没有差异。结论是，在没有进食和运动的情况下，许多马血浆血浆电解质和酸碱参数会出现波动，并且其中一些变化可能是由于每日变化所致。

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