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首页> 外文期刊>Equine and Comparative Exercise Physiology >Effect of detomidine on postural sway in horses.
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Effect of detomidine on postural sway in horses.

机译：地托米定对马的姿势摆动的影响。

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摘要

The objective of this study was to apply postural sway analysis to measure balance deficits after intravenous administration of detomidine. Six healthy horses were treated intravenously with detomidine (10 micro g kg-1, 20 micro g kg-1) and saline in random order, with three days between treatments. Postural sway was measured immediately after administration and at 15 min intervals until 120 min had elapsed. Horses stood squarely with all four hooves on a force platform, while the location of the centre of pressure (COP) was recorded continuously for 10 s at 1000 Hz. Five 10 s recordings were analysed and average values calculated for mediolateral COP range of motion, craniocaudal COP range of motion, mean COP radius, COP area and mean COP velocity. All COP variables increased immediately after sedation, but generally returned to normal limits within 15 and 30 min of detomidine administration at 10 and 20 micro g kg-1, respectively. The head was lowered for at least 90 min after administration. Balance is affected by detomidine and normal balance is regained later after a higher dose. Procedures requiring balance should not be performed within 15-30 min of detomidine administration. COP variables are a good indicator of the effect of sedation on postural sway, but head position is not.
机译：这项研究的目的是应用姿势摇摆分析来测量静脉内给予的托托咪定后的平衡缺陷。随机给六只健康的马静脉注射地托米定（10 micro g kg-1，20 micro g kg-1）和生理盐水，每次治疗之间间隔三天。给药后立即测量姿势摇摆，间隔为15分钟，直到经过120分钟为止。马在所有四个蹄子上直立地站立在受力平台上，而压力中心（COP）的位置在1000 Hz下连续记录了10 s。分析了五个10 s的记录，并计算了中外侧COP运动范围，颅尾COP运动范围，平均COP半径，COP面积和平均COP速度的平均值。镇静后，所有COP变量立即增加，但通常在分别以10和20微克kg-1的脱托咪定给药后15和30分钟内恢复到正常极限。给药后，将头降低至少90分钟。地托米定会影响平衡，大剂量服用后会恢复正常平衡。给予托托咪定15-30分钟内不得进行需要平衡的程序。 COP变量可以很好地表明镇静作用对姿势摇摆的影响，但头部位置却不能。

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