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首页> 外文期刊>Epigenetics: official journal of the DNA Methylation Society >Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancy
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Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancy

机译：孕妇在孕期遭受母亲抑郁，焦虑或SSRI药物治疗的全基因组DNA甲基化

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Despite the high prevalence of depression, anxiety, and use of antidepressant medications during pregnancy, there is much uncertainty around the impact of high levels of distress or antidepressant medications on the developing fetus. These intrauterine exposures may lead to epigenetic alterations to the DNA during this vulnerable time of fetal development, which may have important lifetime health consequences. In this study we investigated patterns of genome-wide DNA methylation using the Illumina Infinium Human Methylation450 BeadChip in the umbilical cord blood of neonates exposed to non-medicated maternal depression or anxiety (n = 13), or selective serotonin reuptake inhibitors (SSRIs) during pregnancy (n = 22), relative to unexposed neonates (n = 23). We identified 42 CpG sites with significantly different DNA methylation levels in neonates exposed to non-medicated depression or anxiety relative to controls. CpG site methylation was not significantly different in neonates exposed to SSRIs relative to the controls, after adjusting for multiple comparisons. In neonates exposed either to non-medicated maternal depression or SSRIs, the vast majority of CpG sites displayed lower DNA methylation relative to the controls, but differences were very small. A gene ontology analysis suggests significant clustering of the top genes associated with non-medicated maternal depression/anxiety, related to regulation of transcription, translation, and cell division processes (e.g., negative regulation of translation in response to oxidative stress, regulation of mRNA export from the nucleus, regulation of stem cell division). While the functional consequences of these findings are yet to be determined, these small DNA methylation differences may suggest a possible role for epigenetic processes in the development of neonates exposed to non-medicated maternal depression/anxiety.
机译：尽管在怀孕期间抑郁症，焦虑症和使用抗抑郁药的患病率很高，但高水平的苦恼或抗抑郁药对发育中的胎儿的影响仍存在很多不确定性。这些子宫内暴露可能会在胎儿发育的这个脆弱时期导致DNA的表观遗传学改变，这可能会对终身健康产生重大影响。在这项研究中，我们研究了使用Illumina Infinium Human Methylation450 BeadChip在暴露于未经药物治疗的母亲抑郁症或焦虑症（n = 13）或选择性5-羟色胺再摄取抑制剂（SSRI）的新生儿的脐带血中进行全基因组DNA甲基化的模式。怀孕（n = 22），相对于未暴露的新生儿（n = 23）。我们确定了暴露于非药物性抑郁症或焦虑症的新生儿相对于对照组而言具有明显不同的DNA甲基化水平的42个CpG位点。调整多次比较后，相对于对照组，暴露于SSRIs的新生儿CpG位点甲基化没有显着差异。在暴露于非药物性产妇抑郁症或SSRI的新生儿中，绝大多数CpG位点相对于对照组显示出较低的DNA甲基化，但差异很小。基因本体分析表明，与非药物性产妇抑郁症/焦虑症相关的顶级基因显着聚集，与转录，翻译和细胞分裂过程的调节有关（例如，对氧化应激的翻译负调节，mRNA出口调节）来自细胞核，调节干细胞分裂）。尽管这些发现的功能后果尚待确定，但这些小的DNA甲基化差异可能表明表观遗传过程在暴露于非药物性产妇抑郁/焦虑症的新生儿的发育中可能发挥作用。

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