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首页> 外文期刊>Epigenetics: official journal of the DNA Methylation Society >Novel insights into the plant histone code: lessons from ORC1.
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Novel insights into the plant histone code: lessons from ORC1.

机译：对植物组蛋白代码的新颖见解：来自ORC1的经验教训。

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摘要

Gene expression control depends on the combinatorial presence of various posttranslational modifications of the N-terminal tail of histones, among which acetylation and methylation of lysine residues are the most conspicuous. Effector proteins have been identified that recognize specific histone modifications and transduce the information of the histone code into different degrees of chromatin compaction in either facultative or constitutive heterochromatin. In addition, they also impinge on transcriptional control, either activation or repression, of euchromatic genes. However, a large variety of effector proteins lead to different gene expression readouts. This is complicated by accumulating evidence showing that the consequences of various histone modifications differ among animals and plants. Given the conservation of histone marks, and histone modification enzymes, this has evolutionary implications as to how they are interpreted differently in different organisms. One example that illustrates such diversity of the histone code is the large subunit of the origin recognition complex, ORC1. In plants, but not in yeast and animal cells, ORC1 functions as a transcriptional activator of a subset of target genes and is a plant homeodomain (PHD)-containing protein that binds to histone H3K4me3 residues.
机译：基因表达控制取决于组蛋白N末端尾部的各种翻译后修饰的组合存在，其中赖氨酸残基的乙酰化和甲基化最为明显。已经鉴定出效应蛋白，其识别特定的组蛋白修饰并将组蛋白编码的信息转化为兼性或组成型异染色质中不同程度的染色质压实。另外，它们也影响常染色体基因的转录控制，无论是激活还是抑制。然而，多种效应蛋白导致不同的基因表达读数。越来越多的证据表明，各种组蛋白修饰的结果在动植物之间是不同的，这使情况变得复杂。考虑到组蛋白标记和组蛋白修饰酶的保守性，这对它们在不同生物体中的不同解释具有进化意义。说明组蛋白代码多样性的一个例子是起源识别复合体ORC1的大子单元。在植物中，而不在酵母和动物细胞中，ORC1充当靶基因子集的转录激活因子，并且是与组蛋白H3K4me3残基结合的含植物同源域（PHD）的蛋白质。

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