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首页> 外文期刊>Epigenetics: official journal of the DNA Methylation Society >Histone H3 phosphorylation: universal code or lineage specific dialects?
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Histone H3 phosphorylation: universal code or lineage specific dialects?

机译：组蛋白H3磷酸化：通用代码还是特定于方言的方言？

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摘要

Post-translational modifications of histones modulate the functional landscape of chromatin and impinge on many DNA-mediated processes. Phosphorylation of histone H3 plays a role in the regulation of gene expression and in chromosome condensation/segregation. Certain evolutionarily conserved residues on histone H3, namely Thr3, Ser10, Thr11 and Ser28, are phosphorylated during interphase or mitosis in both metazoa and plants. However, many of the kinases involved in these events appear to have evolved independently in different lineages. Likewise, the mechanistic function of specific phosphorylated amino acids, although poorly understood, also seems to differ among eukaryotes. Moreover, some modifications, such as phosphorylation of histone H3 Ser10, appear to have both a positive and a negative connotation and only become meaningful in combination with other histone marks within a particular chromatin context. Thus, a detailed understanding of the influence of histone H3 phosphorylation on biological processes may require learning organismal dialects of the histone code.
机译：组蛋白的翻译后修饰可调节染色质的功能范围，并影响许多DNA介导的过程。组蛋白H3的磷酸化在调节基因表达和染色体浓缩/分离中起作用。组蛋白H3上某些进化保守的残基，即Thr3，Ser10，Thr11和Ser28，在后生和植物的相间或有丝分裂期间被磷酸化。但是，参与这些事件的许多激酶似乎在不同谱系中独立发生了进化。同样，特定磷酸化氨基酸的机制功能虽然鲜为人知，但在真核生物之间似乎也有所不同。此外，某些修饰，例如组蛋白H3 Ser10的磷酸化，似乎具有正负两个含义，并且仅在特定染色质范围内与其他组蛋白标记结合才有意义。因此，对组蛋白H3磷酸化对生物过程影响的详细了解可能需要学习组蛋白代码的有机方言。

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